Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
文献类型:期刊论文
作者 | JONES ERIC D ; VANDEGRAAFF NICK ; LE GIANG ; CHOI NEIL0 ; ISSA WILLIAM ; MACFARLANE KATHERINE ; THIENTHONG NEERANAT ; WINFIELD LISA J ; COATES JONATHAN A V ; Lv L(吕龙) ; LI XINMING ; FENG XIAO ; YU CHANGJIANG ; RHODES DAVID I ; DEADMAN JOHN J |
刊名 | Bioorg. Med. Chem. Lett.
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出版日期 | 2010 |
卷号 | 20期号:19页码:5913-5917 |
ISSN号 | 0960-894X |
其他题名 | Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold |
通讯作者 | DEADMAN JOHN J |
英文摘要 | HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells. (C) 2010 Elsevier Ltd. All rights reserved. |
学科主题 | 氟化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1016/j.bmcl.2010.07.079 |
语种 | 英语 |
WOS记录号 | WOS:000281735600068 |
公开日期 | 2013-02-25 |
源URL | [http://202.127.28.38/handle/331003/19231] ![]() |
专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
推荐引用方式 GB/T 7714 | JONES ERIC D,VANDEGRAAFF NICK,LE GIANG,et al. Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold[J]. Bioorg. Med. Chem. Lett.,2010,20(19):5913-5917. |
APA | JONES ERIC D.,VANDEGRAAFF NICK.,LE GIANG.,CHOI NEIL0.,ISSA WILLIAM.,...&DEADMAN JOHN J.(2010).Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold.Bioorg. Med. Chem. Lett.,20(19),5913-5917. |
MLA | JONES ERIC D,et al."Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold".Bioorg. Med. Chem. Lett. 20.19(2010):5913-5917. |
入库方式: OAI收割
来源:上海有机化学研究所
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