中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold

文献类型:期刊论文

作者JONES ERIC D ; VANDEGRAAFF NICK ; LE GIANG ; CHOI NEIL0 ; ISSA WILLIAM ; MACFARLANE KATHERINE ; THIENTHONG NEERANAT ; WINFIELD LISA J ; COATES JONATHAN A V ; Lv L(吕龙) ; LI XINMING ; FENG XIAO ; YU CHANGJIANG ; RHODES DAVID I ; DEADMAN JOHN J
刊名Bioorg. Med. Chem. Lett.
出版日期2010
卷号20期号:19页码:5913-5917
ISSN号0960-894X
其他题名Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
通讯作者DEADMAN JOHN J
英文摘要HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题氟化学
收录类别SCI
原文出处http://dx.doi.org/10.1016/j.bmcl.2010.07.079
语种英语
WOS记录号WOS:000281735600068
公开日期2013-02-25
源URL[http://202.127.28.38/handle/331003/19231]  
专题上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式
GB/T 7714
JONES ERIC D,VANDEGRAAFF NICK,LE GIANG,et al. Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold[J]. Bioorg. Med. Chem. Lett.,2010,20(19):5913-5917.
APA JONES ERIC D.,VANDEGRAAFF NICK.,LE GIANG.,CHOI NEIL0.,ISSA WILLIAM.,...&DEADMAN JOHN J.(2010).Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold.Bioorg. Med. Chem. Lett.,20(19),5913-5917.
MLA JONES ERIC D,et al."Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold".Bioorg. Med. Chem. Lett. 20.19(2010):5913-5917.

入库方式: OAI收割

来源:上海有机化学研究所

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