Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report
文献类型：期刊论文
| 作者 | WANG J ; ZHOU Y ; XU M ; RANG R ; Guo YL(郭寅龙) ; Zhu TY(朱同玉) |
| 刊名 | Transplant. Proc.
 |
| 出版日期 | 2011 |
| 卷号 | 43期号:10页码:3738-3742 |
| ISSN号 | 0041-1345 |
| 其他题名 | Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report |
| 通讯作者 | 朱同玉 |
| 英文摘要 | Acute tubular injury (AT!) is very common in biopsy specimens from renal allografts that suffer from delayed graft function (DGF) or dysfunction. Currently there are few reports on investigating small molecule metabolites in urine samples from transplant recipients as a noninvasive method to predict the ATI of renal allografts instead of an allograft biopsy. In our study matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS) was used to analyze small molecule metabolites in urine samples from renal transplant recipients with biopsy-proven slight ATI or moderate ATI or acute tubular necrosis (ATN). To evaluate the ATI-specific value of those small molecules, we applied the Principal Component Analysis (PCA) program. Mass spectra data were imported into the PCA, where loading graphs were constructed to express the constituents of the urine samples. Slight AT!, moderate ATI, or ATN of renal allografts were separated obviously in the loading graph. The position of urine samples in the graph may reflect the tubular injury status of allografts. A farther apart point from the original site may mean the allograft suffered from more severe AT! (even ATN), and vice versa. Detection of small molecule metabolites in urine samples of recipients through MALDI-FTMS may offer a promising noninvasive, high throughput, rapid tool to predict ATI/ATN of renal allografts. |
| 学科主题 | 分析化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.transproceed.2011.08.109 |
| 语种 | 英语 |
| WOS记录号 | WOS:000298620200031 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/20062]  |
| 专题 | 上海有机化学研究所_分析化学研究室 |
| 推荐引用方式 GB/T 7714 | WANG J,ZHOU Y,XU M,et al. Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report[J]. Transplant. Proc.,2011,43(10):3738-3742. |
| APA | WANG J,ZHOU Y,XU M,RANG R,郭寅龙,&朱同玉.(2011).Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report.Transplant. Proc.,43(10),3738-3742. |
| MLA | WANG J,et al."Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report".Transplant. Proc. 43.10(2011):3738-3742. |
入库方式： OAI收割
来源：上海有机化学研究所
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