Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells
文献类型：期刊论文
| 作者 | Jenny Yuen-Nei Cheung ; Rose Chik-Ying Ong ; Yick-Keung Suen ; Vincent Ooi ; Henry Nai-Ching Wong ; Thomas Chung-Wai MakKwok-Pui Fung ; Yu B(俞飚) ; Siu-Kai Kong |
| 刊名 | Cancer Lett.
 |
| 出版日期 | 2005 |
| 卷号 | 217期号:2页码:203-211 |
| ISSN号 | 0304-3835 |
| 其他题名 | Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells |
| 通讯作者 | Siu-Kai Kong |
| 英文摘要 | In a search for new anticancer agents, we identified a novel compound polyphyllin D (PD) (diosgenyl alpha-L-rhamnopyranosyl(1-->2)-(alpha-L-arabinofuranosyl)-(1-->4)]-[beta -D-glucopyranoside) that induced DNA fragmentation and phosphatidyl-serine (PS) externalization in a hepatocellular carcinoma cell line HepG2 derivative with drug resistance (R-HepG2). PD is a saponin originally found in a tradition Chinese medicinal herb Paris polyphylla. It has been used to treat liver cancer in China for many years. We evaluated the cell-killing mechanisms of this compound in R-HepG2 and its parental cells. The mitochondrial apoptotic pathway was found to be involved in the PD-induced apoptosis because PD elicited depolarization of mitochondrial transmembrane potential (DeltaPsim), generation of H2O2, as well as release of cytochrome c and apoptosis-inducing factor in a dose- and time-dependent manner. In conclusion, we show for the first time that PD is a potent anticancer agent that can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.canlet.2004.06.042 |
| 语种 | 英语 |
| WOS记录号 | WOS:000226476800009 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/19017]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Jenny Yuen-Nei Cheung,Rose Chik-Ying Ong,Yick-Keung Suen,et al. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells[J]. Cancer Lett.,2005,217(2):203-211. |
| APA | Jenny Yuen-Nei Cheung.,Rose Chik-Ying Ong.,Yick-Keung Suen.,Vincent Ooi.,Henry Nai-Ching Wong.,...&Siu-Kai Kong.(2005).Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.Cancer Lett.,217(2),203-211. |
| MLA | Jenny Yuen-Nei Cheung,et al."Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells".Cancer Lett. 217.2(2005):203-211. |
入库方式： OAI收割
来源：上海有机化学研究所
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