Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates
文献类型：期刊论文
| 作者 | Ma YY(马玉勇) ; Li ZZ(李中正) ; Shi HF(史合芳) ; Zhang J(张健) ; Yu B(俞飚) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2011 |
| 卷号 | 76期号:23页码:9748-9756 |
| ISSN号 | 0022-3263 |
| 其他题名 | 以糖基邻炔基苯甲酸酯为给体的金催化糖苷化反应合成digotoxin |
| 通讯作者 | 俞飚 |
| 英文摘要 | Digitoxin, a clinically important cardiac trisactharicle, was assembled efficiently from digitoxigenin and 3,4-di-O-tert-butyldiphenylsilyl-D-digitoxosyl o-cyclopropylethynyl-benzoate in 9 steps and 52% overall yield via alternate glycosylation and protecting group manipulation. The present synthesis showcases the advantage of the gold(I)-catalyzed glycosylation protocol in the synthesis of glycoconjugates containing acid-labile 2-deoxysugar linkages. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo201850z |
| 语种 | 英语 |
| WOS记录号 | WOS:000297274800022 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/19159]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ma YY,Li ZZ,Shi HF,et al. Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates[J]. J. Org. Chem.,2011,76(23):9748-9756. |
| APA | 马玉勇,李中正,史合芳,张健,&俞飚.(2011).Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates.J. Org. Chem.,76(23),9748-9756. |
| MLA | 马玉勇,et al."Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates".J. Org. Chem. 76.23(2011):9748-9756. |
入库方式： OAI收割
来源：上海有机化学研究所
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