Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography
文献类型：期刊论文
| 作者 | Wen Yi; Wang Ying; Zhou Bing-Sheng; Xu Ying; Feng Yu-Qi |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 35期号:5页码:681-684 |
| ISSN号 | 0253-3820 |
| 关键词 | polymer monolith microextraction high performance liquid chromatography sexual hormones liquid cosmetics |
| 通讯作者 | Feng, YQ, Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China |
| 中文摘要 | A method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%. |
| 英文摘要 | A method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%. |
| 学科主题 | Chemistry ; Analytical |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SOLID-PHASE MICROEXTRACTION ; CAPILLARY ; DRUGS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246993300013 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/8566]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen Yi,Wang Ying,Zhou Bing-Sheng,et al. Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2007,35(5):681-684. |
| APA | Wen Yi,Wang Ying,Zhou Bing-Sheng,Xu Ying,&Feng Yu-Qi.(2007).Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,35(5),681-684. |
| MLA | Wen Yi,et al."Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35.5(2007):681-684. |
入库方式： OAI收割
来源：水生生物研究所
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