Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids
文献类型：期刊论文
| 作者 | Li Y(李云) ; Zhang Q(张琦) ; Sergio Wittlin ; Jin HX(金红霞) ; Wu YK(伍贻康) |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2009 |
| 卷号 | 65期号:34页码:6972-6985 |
| ISSN号 | 0040-4020 |
| 其他题名 | Peroxyplakoric酸螺环类似物的合成及体外抗疟活性 |
| 通讯作者 | 伍贻康 |
| 英文摘要 | Four 1,2,7-trioxa-spiro[5.5]undecanes and two 1,6,7-trioxa-spiro[4.5]decanes were synthesized using the hydrogen peroxide in UHP (urea-H2O2 complex) as the source of the peroxy bond. Incorporation of H2O2 into the organic molecular framework was facilitated by the potential to form a five- or six memberd cyclic hemiketal. Saturation of the double bond in a substituted gamma-keto-butenal. a step required in all the syntheses, was achieved in one case with NaI/concd HCl at low temperature without cleaving the TBS protecting group or causing excessive side reactions as observed at ambient temperature. All these peroxides showed in vitro antimalarial activity comparable to that of natural peroxyplakoric acids and the known analogues. (C) 2009 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tet.2009.06.050 |
| 语种 | 英语 |
| WOS记录号 | WOS:000269282400029 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/20419]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li Y,Zhang Q,Sergio Wittlin,et al. Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids[J]. Tetrahedron,2009,65(34):6972-6985. |
| APA | 李云,张琦,Sergio Wittlin,金红霞,&伍贻康.(2009).Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids.Tetrahedron,65(34),6972-6985. |
| MLA | 李云,et al."Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids".Tetrahedron 65.34(2009):6972-6985. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。