RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine
文献类型：期刊论文
| 作者 | Cong X(丛欣) ; Liao QJ(廖清江) ; Yao ZJ(姚祝军) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2004 |
| 卷号 | 69期号:16页码:5314-5321 |
| ISSN号 | 0022-3263 |
| 其他题名 | 从L-丝氨酸出发利用RCM方法非对映选择性合成反式邻二氨基环烷醇 |
| 通讯作者 | 姚祝军 |
| 英文摘要 | Starting from L-serine, the asymmetric synthesis of four diaminocyclitol derivatives as sugar-based glycosidase inhibitors has been achieved using ring-closing metathesis (RCM) as a key step. Introduction of vicinal trans-diamino functionality onto the acyclic precursors was accomplished by highly diastereoselective addition of Grignard reagent to imine, and the elaboration of polyhydroxylic groups was effected via diastereoselective olefin epoxidation or dihydroxylation. The absolute configurations of final products were confirmed by 2D NMR studies. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo0496547 |
| 语种 | 英语 |
| WOS记录号 | WOS:000223008100020 |
| 公开日期 | 2013-02-26 |
| 源URL | [http://202.127.28.38/handle/331003/21049]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Cong X,Liao QJ,Yao ZJ. RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine[J]. J. Org. Chem.,2004,69(16):5314-5321. |
| APA | 丛欣,廖清江,&姚祝军.(2004).RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine.J. Org. Chem.,69(16),5314-5321. |
| MLA | 丛欣,et al."RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine".J. Org. Chem. 69.16(2004):5314-5321. |
入库方式： OAI收割
来源：上海有机化学研究所
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