Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)
文献类型：期刊论文
| 作者 | Song, S. B.; Xu, Y.; Zhou, B. S. |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2006-10-01 |
| 卷号 | 65期号:4页码:699-706 |
| 关键词 | acetylcholinesterase antioxidant enzymes glutathione lipid peroxidation (LPO) oxidative stress reactive oxygen species |
| ISSN号 | 0045-6535 |
| 通讯作者 | Xu, Y, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu S Rd 7, Wuhan 430072, Peoples R China |
| 中文摘要 | Hexachlorobenzene (HCB)-induced oxidative damages have been published in rats while the effects have not yet been reported in fishes. Juvenile common carps (Cyprinus carpio) were exposed to waterborne HCB from 2 to 200 mu g l(-1) for 5, 10 or 20 days. Liver and brain were analyzed for various parameters of oxidative stress. There were no significant changes of glutathione (GSH) content and superoxide dismutase (SOD) activity in liver after 5 or 10 days exposure, whereas obvious drops were observed at higher concentrations after 20 days exposure. Significant decreases of GSH content and SOD activity in brain were found during all the exposure days. In brain, HCB also significantly elevated the contents of reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS, as an indicator of lipid peroxidation products), glutathione disulfide (GSSG), and activities of nitric oxide synthase (NOS), glutathione peroxidase (GPx), and glutathione reductase (GR), and inhibited activities of acetylcholinesterase (AchE) and glutathione S-transferase (GST). The results clearly demonstrated that environmentally possible level of HCB could result in oxidative stress in fish and brain was a sensitive target organ of HCB toxicity. (c) 2006 Elsevier Ltd. All rights reserved. |
| 英文摘要 | Hexachlorobenzene (HCB)-induced oxidative damages have been published in rats while the effects have not yet been reported in fishes. Juvenile common carps (Cyprinus carpio) were exposed to waterborne HCB from 2 to 200 mu g l(-1) for 5, 10 or 20 days. Liver and brain were analyzed for various parameters of oxidative stress. There were no significant changes of glutathione (GSH) content and superoxide dismutase (SOD) activity in liver after 5 or 10 days exposure, whereas obvious drops were observed at higher concentrations after 20 days exposure. Significant decreases of GSH content and SOD activity in brain were found during all the exposure days. In brain, HCB also significantly elevated the contents of reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS, as an indicator of lipid peroxidation products), glutathione disulfide (GSSG), and activities of nitric oxide synthase (NOS), glutathione peroxidase (GPx), and glutathione reductase (GR), and inhibited activities of acetylcholinesterase (AchE) and glutathione S-transferase (GST). The results clearly demonstrated that environmentally possible level of HCB could result in oxidative stress in fish and brain was a sensitive target organ of HCB toxicity. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | FRESH-WATER FISH ; GLUTATHIONE S-TRANSFERASES ; OXYGEN SPECIES PRODUCTION ; OXIDATIVE STRESS ; RAT-BRAIN ; EXPOSURE ; ENZYMES ; METABOLISM ; INDUCTION ; PORPHYRIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241652000022 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/8806]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, S. B.,Xu, Y.,Zhou, B. S.. Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)[J]. CHEMOSPHERE,2006,65(4):699-706. |
| APA | Song, S. B.,Xu, Y.,&Zhou, B. S..(2006).Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio).CHEMOSPHERE,65(4),699-706. |
| MLA | Song, S. B.,et al."Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)".CHEMOSPHERE 65.4(2006):699-706. |
入库方式： OAI收割
来源：水生生物研究所
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