Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis
文献类型：期刊论文
| 作者 | Lutz, I; Jie, Z; Opitz, R; Kloas, W; Ying, X; Menzel, R; Steinberg, CEW |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2005-12-01 |
| 卷号 | 61期号:8页码:1183-1188 |
| 关键词 | estrogenic effect ER-mRNA TSH beta-mRNA clawed frog molecular biomarkers |
| ISSN号 | 0045-6535 |
| 通讯作者 | Steinberg, CEW, Leibniz Inst Freshwater Ecol & Inland Fisheries, Muggelseedamm 310, D-12587 Berlin, Germany |
| 中文摘要 | According to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved. |
| 英文摘要 | According to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | SIZE-EXCLUSION CHROMATOGRAPHY ; DISSOLVED ORGANIC-MATTER ; ENDOCRINE DISRUPTORS ; CAENORHABDITIS-ELEGANS ; MASS-SPECTROMETRY ; AMPHIBIANS ; CHEMICALS ; MODEL ; REPRODUCTION ; ACIDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000233381100014 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/9100]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Leibniz Inst Freshwater Ecol & Inland Fisheries, D-12587 Berlin, Germany 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 3.Humboldt Univ, Inst Biol, D-10099 Berlin, Germany |
| 推荐引用方式 GB/T 7714 | Lutz, I,Jie, Z,Opitz, R,et al. Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis[J]. CHEMOSPHERE,2005,61(8):1183-1188. |
| APA | Lutz, I.,Jie, Z.,Opitz, R.,Kloas, W.,Ying, X.,...&Steinberg, CEW.(2005).Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis.CHEMOSPHERE,61(8),1183-1188. |
| MLA | Lutz, I,et al."Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis".CHEMOSPHERE 61.8(2005):1183-1188. |
入库方式： OAI收割
来源：水生生物研究所
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