Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism
文献类型：期刊论文
| 作者 | Yang, FX; Xu, Y |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 17期号:4页码:740-748 |
| ISSN号 | 1005-281X |
| 关键词 | polychlorinated biphenyls hydroxylated polychlorinated biphenyls OH-PCBs endocrine disruption |
| 通讯作者 | Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 中文摘要 | Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China. |
| 英文摘要 | Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China. |
| 学科主题 | Chemistry ; Multidisciplinary |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CEREBELLAR GRANULE CELLS ; ESTROGEN-RECEPTOR ; PCB METABOLITES ; METHYL SULFONE ; BINDING ; CONGENERS ; TRANSTHYRETIN ; PLASMA ; 3,4,3',4'-TETRACHLOROBIPHENYL ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230693700022 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/9204]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, FX,Xu, Y. Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism[J]. PROGRESS IN CHEMISTRY,2005,17(4):740-748. |
| APA | Yang, FX,&Xu, Y.(2005).Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism.PROGRESS IN CHEMISTRY,17(4),740-748. |
| MLA | Yang, FX,et al."Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism".PROGRESS IN CHEMISTRY 17.4(2005):740-748. |
入库方式： OAI收割
来源：水生生物研究所
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