Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi
文献类型：期刊论文
| 作者 | Sun, BJ; Nie, P |
| 刊名 | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
 |
| 出版日期 | 2004-10-01 |
| 卷号 | 101期号:3-4页码:161-170 |
| 关键词 | viperin gene organization promoter mandarin fish Chinese perch Siniperca chuatsi |
| ISSN号 | 0165-2427 |
| 通讯作者 | Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
| 中文摘要 | A viperin gene has been cloned from the mandarin fish (Siniperca chuatsi). From the first transcription initiation site, the mandarin fish viperin gene extends 3163 nucleotides to the end of the 3' untranslated region, and it contains six exons and five introns. The open reading frame of the viperin transcript has 1062 nucleotides which encode a 354 amino acid peptide. The amino acid sequence of mandarin fish viperin shows high identities with its homologues in teleosts and mammals except for the first 70 amino acids. A characteristic feature in the viperin promoter region was the presence of five putative ICSBP (IRF8) binding sites and one IRFI binding site. The viperin gene expressed mainly in lymphoid tissues before stimulation, but its expression can be examined in almost all the organs investigated after stimulation with virus or Poly I:C. The expression pattern and promoter sequence may be considered as the indirect evidence that the transcription of viperin is regulated by interferons or interferon induced genes. (C) 2004 Elsevier B.V. All rights reserved. |
| 英文摘要 | A viperin gene has been cloned from the mandarin fish (Siniperca chuatsi). From the first transcription initiation site, the mandarin fish viperin gene extends 3163 nucleotides to the end of the 3' untranslated region, and it contains six exons and five introns. The open reading frame of the viperin transcript has 1062 nucleotides which encode a 354 amino acid peptide. The amino acid sequence of mandarin fish viperin shows high identities with its homologues in teleosts and mammals except for the first 70 amino acids. A characteristic feature in the viperin promoter region was the presence of five putative ICSBP (IRF8) binding sites and one IRFI binding site. The viperin gene expressed mainly in lymphoid tissues before stimulation, but its expression can be examined in almost all the organs investigated after stimulation with virus or Poly I:C. The expression pattern and promoter sequence may be considered as the indirect evidence that the transcription of viperin is regulated by interferons or interferon induced genes. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Immunology; Veterinary Sciences |
| 类目[WOS] | Immunology ; Veterinary Sciences |
| 研究领域[WOS] | Immunology ; Veterinary Sciences |
| 关键词[WOS] | INTERFERON REGULATORY FACTOR ; VESICULAR STOMATITIS-VIRUS ; TROUT ONCORHYNCHUS-MYKISS ; RAINBOW-TROUT ; FUNCTIONAL-CHARACTERIZATION ; HUMAN CYTOMEGALOVIRUS ; PROTEIN ; EXPRESSION ; IDENTIFICATION ; GENERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224154600004 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/9416]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Lab Fish Dis, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, BJ,Nie, P. Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2004,101(3-4):161-170. |
| APA | Sun, BJ,&Nie, P.(2004).Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,101(3-4),161-170. |
| MLA | Sun, BJ,et al."Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 101.3-4(2004):161-170. |
入库方式： OAI收割
来源：水生生物研究所
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