Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout
文献类型：期刊论文
| 作者 | Zhang, YA; Zou, J; Chang, CI; Secombes, CJ |
| 刊名 | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
 |
| 出版日期 | 2004-10-01 |
| 卷号 | 101期号:3-4页码:259-269 |
| 关键词 | LEAP-2 antimicrobial peptide liver rainbow trout teleost |
| ISSN号 | 0165-2427 |
| 通讯作者 | Secombes, CJ, Univ Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Zool Bldg,Tillydrone Ave, Aberdeen AB24 2TZ, Scotland |
| 中文摘要 | The sequences and gene organisation of two LEAP-2 molecules (LEAP-2A and LEAP-2B) from rainbow trout, Oncorhynchus mykiss are presented. Both genes consist of a 3 exon/2 intron structure, with exon sizes comparable to known mammalian genes. LEAP-2A notably differs from LEAP-2B in having larger introns and a larger 3'UTR. The predicted proteins contain a signal peptide and prodomain, followed by a mature peptide of 41 aa containing four conserved cysteines. The RXXR cleavage site to release the mature peptide was also conserved. Both genes were found to be constitutively expressed in the liver, with expression in the intestine, and to a lesser extent the skin, evident after bacterial challenge. (C) 2004 Elsevier B.V. All rights reserved. |
| 英文摘要 | The sequences and gene organisation of two LEAP-2 molecules (LEAP-2A and LEAP-2B) from rainbow trout, Oncorhynchus mykiss are presented. Both genes consist of a 3 exon/2 intron structure, with exon sizes comparable to known mammalian genes. LEAP-2A notably differs from LEAP-2B in having larger introns and a larger 3'UTR. The predicted proteins contain a signal peptide and prodomain, followed by a mature peptide of 41 aa containing four conserved cysteines. The RXXR cleavage site to release the mature peptide was also conserved. Both genes were found to be constitutively expressed in the liver, with expression in the intestine, and to a lesser extent the skin, evident after bacterial challenge. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Immunology; Veterinary Sciences |
| 类目[WOS] | Immunology ; Veterinary Sciences |
| 研究领域[WOS] | Immunology ; Veterinary Sciences |
| 关键词[WOS] | ANTIBACTERIAL PEPTIDES ; FISH ; IDENTIFICATION ; HEPCIDIN ; SKIN ; BASS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224154600014 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/9418]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Univ Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 3.Fisheries Res Inst, Chilung, Taiwan |
| 推荐引用方式 GB/T 7714 | Zhang, YA,Zou, J,Chang, CI,et al. Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2004,101(3-4):259-269. |
| APA | Zhang, YA,Zou, J,Chang, CI,&Secombes, CJ.(2004).Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,101(3-4),259-269. |
| MLA | Zhang, YA,et al."Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 101.3-4(2004):259-269. |
入库方式： OAI收割
来源：水生生物研究所
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