HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
文献类型：期刊论文
| 作者 | Lin, J; Deng, CS; Sun, J; Zheng, XG; Huang, X; Zhou, Y; Xiong, P; Wang, YP |
| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| 出版日期 | 2003-03-01 |
| 卷号 | 9期号:3页码:412-416 |
| 关键词 | HLA CLASS-II |
| ISSN号 | 1007-9327 |
| 通讯作者 | Lin, J, Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China |
| 中文摘要 | AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs0.1397, P=0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma. |
| 英文摘要 | AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Gastroenterology & Hepatology |
| 类目[WOS] | Gastroenterology & Hepatology |
| 研究领域[WOS] | Gastroenterology & Hepatology |
| 关键词[WOS] | HLA CLASS-II ; POLYMERASE-CHAIN-REACTION ; HUMAN-LEUKOCYTE ANTIGENS ; CYTOTOXIC T-LYMPHOCYTES ; COLORECTAL-CANCER ; CELL-CARCINOMA ; CARCINOEMBRYONIC-ANTIGEN ; PERIPHERAL-BLOOD ; GASTRIC-CANCER ; NORTHERN CHINA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000181745400006 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/9720]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab, Wuhan 430077, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, J,Deng, CS,Sun, J,et al. HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(3):412-416. |
| APA | Lin, J.,Deng, CS.,Sun, J.,Zheng, XG.,Huang, X.,...&Wang, YP.(2003).HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,9(3),412-416. |
| MLA | Lin, J,et al."HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 9.3(2003):412-416. |
入库方式： OAI收割
来源：水生生物研究所
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