Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens
文献类型：期刊论文
| 作者 | JING YU ; XU CHENGGONG ; Ding K(丁凯) ; Lin JR(林静容) ; Jin RH(金荣华) ; Tian WS(田伟生) |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2010 |
| 卷号 | 51期号:24页码:3242-3245 |
| ISSN号 | 0040-4039 |
| 其他题名 | Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens |
| 通讯作者 | 丁凯 ; 田伟生 |
| 英文摘要 | 19-O-Acylation was found to be indispensable for 1,2-dehydrogenation of 19-hydroxyandrost-4-ene-3,17-dione la with DDQ as an oxidant after exploring a variety of C-19 substituents. 1,2-Dehydrogenation in combination with subsequent A-ring aromatization via retro-aldol reaction provided a flexible and efficient protocol for the synthesis of estrogens. To demonstrate the utility of the protocol, pharmaceutically attractive estrogens were synthesized from easily available 19-hydroxy-4-ene-3-keto steroids. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2010.04.070 |
| 语种 | 英语 |
| WOS记录号 | WOS:000278497900021 |
| 公开日期 | 2013-03-11 |
| 源URL | [http://202.127.28.38/handle/331003/23878]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | JING YU,XU CHENGGONG,Ding K,et al. Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens[J]. Tetrahedron Lett.,2010,51(24):3242-3245. |
| APA | JING YU,XU CHENGGONG,丁凯,林静容,金荣华,&田伟生.(2010).Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens.Tetrahedron Lett.,51(24),3242-3245. |
| MLA | JING YU,et al."Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens".Tetrahedron Lett. 51.24(2010):3242-3245. |
入库方式： OAI收割
来源：上海有机化学研究所
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