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Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity
文献类型：期刊论文
| 作者 | Ceng M(曾蜜) ; You SL(游书力) |
| 刊名 | Synlett
 |
| 出版日期 | 2010 |
| 期号 | 9页码:1289-1301 |
| ISSN号 | 0936-5214 |
| 其他题名 | 吲哚的不对称傅克烷基化: 对映体选择性与区域选择性的控制 |
| 通讯作者 | 游书力 |
| 英文摘要 | The asymmetric Friedel-Crafts reaction of indoles is a synthetic methodology that enables direct access to the enantiopure indole derivatives. In this review, work mainly carried out by You and his co-workers on the regio- and enantioselective synthesis of indole derivatives will be discussed. Chiral Bronsted acids or iridium complexes promote highly enantioselective Friedel-Crafts reactions of indoles and 4,7-dihydroindoles starting with various electrophilic reagents, such as imines, N-tosyl-substituted amines, beta,gamma-unsaturated a-keto esters, nitro-substituted olefins, aldehydes, and allyl carbonates. These methodologies can be used to readily prepare diverse enantioenriched indoles, such as indol-3-ylmethanamines, indol-2-ylmethanamines, unsymmetrical arylbis(indol-3-yl)methanes, 9-indol-3-ylfluorenes, tetrahydropyrano[3,4-b]indoles, tetrahydro-gamma-carbolines, and tetrahydro-beta-carbolines. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1055/s-0029-1219929 |
| 语种 | 英语 |
| WOS记录号 | WOS:000278408800001 |
| 公开日期 | 2013-03-04 |
| 源URL | [http://202.127.28.38/handle/331003/22520]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ceng M,You SL. Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity[J]. Synlett,2010(9):1289-1301. |
| APA | 曾蜜,&游书力.(2010).Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity.Synlett(9),1289-1301. |
| MLA | 曾蜜,et al."Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity".Synlett .9(2010):1289-1301. |
入库方式： OAI收割
来源：上海有机化学研究所
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