Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers
文献类型：期刊论文
| 作者 | Zhu YD(朱英丹) ; Sheng RL(盛瑞隆) ; Luo T(罗挺) ; Li H(李慧) ; Sun WY(孙文艳) ; Cao AM(曹阿民) |
| 刊名 | Macromol. Biosci.
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:2页码:174-186 |
| ISSN号 | 1616-5187 |
| 其他题名 | 两亲性树枝状赖氨酸-聚乳酸-树枝状赖氨酸的溶液自组装与基因转染行为 |
| 通讯作者 | 曹阿民 |
| 英文摘要 | A new series of triblock [dendritic poly(L-lysine)]-block-PLLA-block-[dendritic poly(L-lysine)]s(DL2-PLLA-DL2) with PLLA block lengths of 11.5-26.5 and double 2-generation PLL dendrons DL2 as model cationic amphiphiles were synthesized and characterized. Their CAC, self-aggregation and plasmid DNA binding affinities in pure water and PBS were studied. The PLLA block length dependence of particle size, morphology and xi potential for organized pDNA/amphiphile polyplex aggregates were examined. Finally, toxicities of these DL2-PLLA-DL2 amphiphiles and their polyplexes were assayed by MTT with HeLa, SMMC-7721 and COS-7 cells, and COS-7 cell luciferase and eGFP gene transfection efficacies with these amphiphiles as the delivery carriers were investigated. |
| 学科主题 | 高分子化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/mabi.201000225 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287162800002 |
| 公开日期 | 2013-03-07 |
| 源URL | [http://202.127.28.38/handle/331003/22958]  |
| 专题 | 上海有机化学研究所_高分子材料研究室 |
| 推荐引用方式 GB/T 7714 | Zhu YD,Sheng RL,Luo T,et al. Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers[J]. Macromol. Biosci.,2011,11(2):174-186. |
| APA | 朱英丹,盛瑞隆,罗挺,李慧,孙文艳,&曹阿民.(2011).Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers.Macromol. Biosci.,11(2),174-186. |
| MLA | 朱英丹,et al."Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers".Macromol. Biosci. 11.2(2011):174-186. |
入库方式： OAI收割
来源：上海有机化学研究所
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