A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression
文献类型：期刊论文
| 作者 | Yang, ZG; Liu, NG; Lin, S |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2001-03-01 |
| 卷号 | 231期号:1页码:138-148 |
| ISSN号 | 0012-1606 |
| 关键词 | zebrafish forebrain zinc finger protein |
| 通讯作者 | Lin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA |
| 中文摘要 | Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecular events underlying vertebrate forebrain determination and specification. Here we report the sequence and characterization of fez (forebrain embryonic zinc finger), a gene that is specifically expressed in the embryonic forebrain of zebrafish. Fez encodes a putative nuclear zinc finger protein that is highly conserved in Drosophila, zebrafish, Xenopus, mouse, and human. In zebrafish, the expression of fez becomes detectable at the anterior edge of the presumptive neuroectoderm by 70% epiboly. During the segmentation period, its expression is completely restricted to the rostral region of the prospective forebrain. At approximately 24 h postfertilization, fez expression is mostly confined to the telencephalon and the anterior-ventral region of the diencephalon. Although fez expression is present in one-eyed pinhead (oep) and cyclops (cyc) zebrfish mutants, the pattern is altered. Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development. Knockdown of fez function using a morpholino-based antisense oligo inhibited dlx2 expression in the ventral forebrain. Our studies indicate that fez is one of the earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain development by regulating Dlx gene expression. (C) 2001 Academic Press. |
| 英文摘要 | Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecular events underlying vertebrate forebrain determination and specification. Here we report the sequence and characterization of fez (forebrain embryonic zinc finger), a gene that is specifically expressed in the embryonic forebrain of zebrafish. Fez encodes a putative nuclear zinc finger protein that is highly conserved in Drosophila, zebrafish, Xenopus, mouse, and human. In zebrafish, the expression of fez becomes detectable at the anterior edge of the presumptive neuroectoderm by 70% epiboly. During the segmentation period, its expression is completely restricted to the rostral region of the prospective forebrain. At approximately 24 h postfertilization, fez expression is mostly confined to the telencephalon and the anterior-ventral region of the diencephalon. Although fez expression is present in one-eyed pinhead (oep) and cyclops (cyc) zebrfish mutants, the pattern is altered. Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development. Knockdown of fez function using a morpholino-based antisense oligo inhibited dlx2 expression in the ventral forebrain. Our studies indicate that fez is one of the earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain development by regulating Dlx gene expression. (C) 2001 Academic Press. |
| 学科主题 | Developmental Biology |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Developmental Biology |
| 研究领域[WOS] | Developmental Biology |
| 关键词[WOS] | BONE MORPHOGENETIC PROTEIN-4 ; ONE-EYED PINHEAD ; PRIMITIVE ENDODERM ; DANIO-RERIO ; NO TAIL ; XENOPUS ; GASTRULATION ; ORGANIZER ; MOUSE ; HEAD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000167271000011 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/10032]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA 2.Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, ZG,Liu, NG,Lin, S. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression[J]. DEVELOPMENTAL BIOLOGY,2001,231(1):138-148. |
| APA | Yang, ZG,Liu, NG,&Lin, S.(2001).A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression.DEVELOPMENTAL BIOLOGY,231(1),138-148. |
| MLA | Yang, ZG,et al."A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression".DEVELOPMENTAL BIOLOGY 231.1(2001):138-148. |
入库方式： OAI收割
来源：水生生物研究所
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