Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry
文献类型：期刊论文
| 作者 | Niu J ; Pi ZF ; Yue H ; Yang HM ; Wang Y ; Yu Q ; Liu SY |
| 刊名 | rapid communications in mass spectrometry
 |
| 出版日期 | 2012 |
| 卷号 | 26期号:23页码:2683-2689 |
| 关键词 | MASS-SPECTROMETRY PANAX-GINSENG BILE-ACIDS METABOLISM MODEL MECHANISM COMPONENT EXTRACT TISSUES AMPK |
| ISSN号 | 0951-4198 |
| 通讯作者 | liu sy |
| 中文摘要 | rationale 20(s)-ginsenoside rg3 is an active component of panax ginseng. it is known that 20(s)-ginsenoside rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated. methods a urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (rrlc/ms) was developed to investigate the effect of 20(s)-ginsenoside rg3 on type 2 diabetic rats. results with multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(s)-ginsenoside rg3 was achieved. six potential biomarkers were found and identified. conclusions this work shows that the mechanism of the effect of 20(s)-ginsenoside rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism. copyright (c) 2012 john wiley & sons, ltd. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310676700005 |
| 公开日期 | 2013-03-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47792]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Niu J,Pi ZF,Yue H,et al. Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry[J]. rapid communications in mass spectrometry,2012,26(23):2683-2689. |
| APA | Niu J.,Pi ZF.,Yue H.,Yang HM.,Wang Y.,...&Liu SY.(2012).Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry.rapid communications in mass spectrometry,26(23),2683-2689. |
| MLA | Niu J,et al."Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry".rapid communications in mass spectrometry 26.23(2012):2683-2689. |
入库方式： OAI收割
来源：长春应用化学研究所
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