Turn-On Fluorescence Sensor Based on Single-Walled-Carbon-Nanohorn-Peptide Complex for the Detection of Thrombin
文献类型：期刊论文
| 作者 | Zhu SY ; Liu ZY ; Hu LZ ; Yuan YL ; Xu GB |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2012 |
| 卷号 | 18期号:51页码:16556-16561 |
| 关键词 | CHARGE-TRANSFER PROTEASE ASSAY NANOTUBES FUNCTIONALIZATION PLATFORM DATABASE POLYMER MEROPS LABEL |
| ISSN号 | 0947-6539 |
| 通讯作者 | xu gb |
| 中文摘要 | proteases play a central role in several widespread diseases. thus, there is a great need for the fast and sensitive detection of various proteolytic enzymes. herein, we have developed a carbon nanotube (cnt)-based protease biosensing platform that uses peptides as a fluorescence probe for the first time. single-walled carbon nanohorns (swcnhs) and thrombin were used to demonstrate this detection strategy. swcnhs can adsorb a fluorescein-based dye (fam)-labeled peptide (fam-pep) and quench the fluorescence of fam. in contrast, thrombin can cleave fam-pep on swcnhs and recover the fluorescence of fam, which allows the sensitive detection of thrombin. this biosensor has a high sensitivity and selectivity toward thrombin, with a detection limit of 100 pm. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312275200036 |
| 公开日期 | 2013-03-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47802]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhu SY,Liu ZY,Hu LZ,et al. Turn-On Fluorescence Sensor Based on Single-Walled-Carbon-Nanohorn-Peptide Complex for the Detection of Thrombin[J]. chemistry-a european journal,2012,18(51):16556-16561. |
| APA | Zhu SY,Liu ZY,Hu LZ,Yuan YL,&Xu GB.(2012).Turn-On Fluorescence Sensor Based on Single-Walled-Carbon-Nanohorn-Peptide Complex for the Detection of Thrombin.chemistry-a european journal,18(51),16556-16561. |
| MLA | Zhu SY,et al."Turn-On Fluorescence Sensor Based on Single-Walled-Carbon-Nanohorn-Peptide Complex for the Detection of Thrombin".chemistry-a european journal 18.51(2012):16556-16561. |
入库方式： OAI收割
来源：长春应用化学研究所
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