Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery
文献类型：期刊论文
| 作者 | Zhou DF ; Xiao HH ; Meng FB ; Zhou SY ; Guo JS ; Li XY ; Jing XB ; Huang YB |
| 刊名 | bioconjugate chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 23期号:12页码:2335-2343 |
| 关键词 | POLYELECTROLYTE MULTILAYER FILMS POLYMER THERAPEUTICS TARGETED DELIVERY ANTICANCER DRUGS CLICK CAPSULES GROWTH REGIME CANCER CELLS NANOPARTICLES CISPLATIN TUMOR |
| ISSN号 | 1043-1802 |
| 通讯作者 | meng fb |
| 中文摘要 | platinum(iv), a pro-drug of platinum(ii), was conjugated to poly(l-lysine) (pll), and then assembled with poly(glutamic acid) (pga) through a layer-by-layer (lbl) approach on colloidal silica templates. after removal of the templates, biodegradable pga/pll-pt(iv) multilayer capsules (diameter = 0.5 mu m) with 10 mu g of platinum incorporated into each bilayer were obtained. under acidic and/or reductive conditions, the amount and rate of platinum released from the capsules were increased, which are desirable traits for platinum-based anticancer drug delivery systems. furthermore, in vitro evaluation showed that the pga/pll-pt(iv) multilayer microcapsule's displayed higher cytotoxicity (ic50pt = 3.5 mu g/ml) against colon cancer cells ct-26 than that of free cisplatin (ic50pt = 8.6 mu g/ml). this enhanced cytotoxicity was attributed to the effective internalization of the capsules by the cancer cells, which was observed by confocal laser scanning microscopy (clsm) imaging. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312429900003 |
| 公开日期 | 2013-03-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47805]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou DF,Xiao HH,Meng FB,et al. Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery[J]. bioconjugate chemistry,2012,23(12):2335-2343. |
| APA | Zhou DF.,Xiao HH.,Meng FB.,Zhou SY.,Guo JS.,...&Huang YB.(2012).Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery.bioconjugate chemistry,23(12),2335-2343. |
| MLA | Zhou DF,et al."Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery".bioconjugate chemistry 23.12(2012):2335-2343. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。