Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery
文献类型：期刊论文
| 作者 | Kang XJ ; Dai YL ; Ma PA ; Yang DM ; Li CX ; Hou ZY ; Cheng ZY ; Lin J |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2012 |
| 卷号 | 18期号:49页码:15676-15682 |
| 关键词 | SUSTAINED-RELEASE PROPERTY MESOPOROUS SPHERES SILICA SPHERES CANCER-THERAPY NANOPARTICLES CARRIERS LUMINESCENT NANOCRYSTALS CONTAINERS SYSTEM |
| ISSN号 | 0947-6539 |
| 通讯作者 | cheng zy |
| 中文摘要 | monodisperse poly(acrylic acid)-modified fe3o4 (paa@fe3o4) hybrid microspheres with dual responses (magnetic field and ph) were successfully fabricated. the paa polymer was encapsulated into the inner cavity of fe3o4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. tem images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. the fe3o4 spheres, after modification with the paa polymer, still possess enough space to hold guest molecules. we selected doxorubicin (dox) as a model drug to investigate the drug loading and release behavior of as-prepared composites. the release of dox molecules was strongly dependent on the ph value due to the unique property of paa. the hela cell-uptake process of dox-loaded paa@fe3o4 was observed by confocal laser scanning microscopy (clsm). after being incubated with hela cells under magnet magnetically guided conditions, the cytotoxtic effects of dox-loaded paa@fe3o4 increased. these results indicate that ph-responsive magnetic paa@fe3o4 spheres have the potential to be used as anticancer drug carriers. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000311438200015 |
| 公开日期 | 2013-03-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47814]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang XJ,Dai YL,Ma PA,et al. Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery[J]. chemistry-a european journal,2012,18(49):15676-15682. |
| APA | Kang XJ.,Dai YL.,Ma PA.,Yang DM.,Li CX.,...&Lin J.(2012).Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery.chemistry-a european journal,18(49),15676-15682. |
| MLA | Kang XJ,et al."Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery".chemistry-a european journal 18.49(2012):15676-15682. |
入库方式： OAI收割
来源：长春应用化学研究所
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