Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry
文献类型：期刊论文
| 作者 | Zhu HB ; Wang CY ; Qi Y ; Song FR ; Liu ZG ; Liu SY |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2012 |
| 卷号 | 752页码:69-77 |
| 关键词 | DIESTER-DITERPENOID ALKALOIDS EMPLOYING DIRECT ANALYSIS CLUSTER-ANALYSIS DART MS IDENTIFICATION SAMPLES ROOTS L. |
| ISSN号 | 0003-2670 |
| 通讯作者 | song fr |
| 中文摘要 | this study presents a novel and rapid method to identify chemical markers for the quality control of radix aconiti preparata, a world widely used traditional herbal medicine. in the method, the samples with a fast extraction procedure were analyzed using direct analysis in real time mass spectrometry (dart ms) combined with multivariate data analysis. at present, the quality assessment approach of radix aconiti preparata was based on the two processing methods recorded in chinese pharmacopoeia for the purpose of reducing the toxicity of radix aconiti and ensuring its clinical therapeutic efficacy. in order to ensure the safety and effectivity in clinical use, the processing degree of radix aconiti should be well controlled and assessed. in the paper, hierarchical cluster analysis and principal component analysis were performed to evaluate the dart ms data of radix aconiti preparata samples in different processing times. the results showed that the well processed radix aconiti preparata, unqualified processed and the raw radix aconiti could be clustered reasonably corresponding to their constituents. the loading plot shows that the main chemical markers having the most influence on the discrimination amongst the qualified and unqualified samples were mainly some monoester diterpenoid aconitines and diester diterpenoid aconitines, i.e. benzoylmesaconine, hypaconitine, mesaconitine, neoline, benzoylhypaconine, benzoylaconine, fuziline, aconitine and 10-oh-mesaconitine. the established dart ms approach in combination with multivariate data analysis provides a very flexible and reliable method for quality assessment of toxic herbal medicine. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310942400008 |
| 公开日期 | 2013-03-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47849]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhu HB,Wang CY,Qi Y,et al. Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry[J]. analytica chimica acta,2012,752:69-77. |
| APA | Zhu HB,Wang CY,Qi Y,Song FR,Liu ZG,&Liu SY.(2012).Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry.analytica chimica acta,752,69-77. |
| MLA | Zhu HB,et al."Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry".analytica chimica acta 752(2012):69-77. |
入库方式： OAI收割
来源：长春应用化学研究所
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