The photocytotoxicity of different lights on mammalian cells in interior lighting system
文献类型：期刊论文
| 作者 | Song, Jiayin1; Gao, Tingting2; Ye, Maole3; Bi, Hongtao2; Liu, Gang1 |
| 刊名 | journal of photochemistry and photobiology b-biology
 |
| 出版日期 | 2012-12-05 |
| 卷号 | 117页码:13-18 |
| 关键词 | Photocytotoxicity Incandescent light LED Mammalian cell ROS Lipid peroxidation |
| ISSN号 | 1011-1344 |
| 中文摘要 | in the present paper, two light sources commonly used in interior lighting system: incandescent light and light emitting diode (led) were chosen to evaluate their influences on three kinds of mammalian cells, together with uva and uvb, and the mechanism of the photocytotoxicity was investigated in terms of intracellular ros production, lipid peroxidation. sod activity and gsh level assays. the results showed that led and incandescent light both had some photocytotoxicities. in the interior lighting condition (100 lx-250 lx), the cytotoxicities of led and incandescent lamp on rf/6a cells (rhesus retinal pigment epithelium cell line) were stronger than that on two fibroblast cell lines, while the cytotoxicity of uva and uvb on hs68 cells (fibroblast cell line) was highest in the tests. the mechanism analysis revealed that the photocytotoxicities of led and incandescent lamp were both caused by cell lipid peroxidation. led and incandescent light could promote the production of ros, raise lipid peroxidation level and lower the activity of the antioxidant key enzymes in mammalian cells, and finally cause a number of cells death. however, the negative function of led was significantly smaller than incandescent light and ultraviolet in daily interior lighting condition. and the significantly lower photocytotoxicity of led might be due to the less existence of ultraviolet. therefore, led is an efficient and relative safe light source in interior lighting system, which should be widely used instead of traditional light source. (c) 2012 elsevier b.v. all rights reserved. |
| 英文摘要 | in the present paper, two light sources commonly used in interior lighting system: incandescent light and light emitting diode (led) were chosen to evaluate their influences on three kinds of mammalian cells, together with uva and uvb, and the mechanism of the photocytotoxicity was investigated in terms of intracellular ros production, lipid peroxidation. sod activity and gsh level assays. the results showed that led and incandescent light both had some photocytotoxicities. in the interior lighting condition (100 lx-250 lx), the cytotoxicities of led and incandescent lamp on rf/6a cells (rhesus retinal pigment epithelium cell line) were stronger than that on two fibroblast cell lines, while the cytotoxicity of uva and uvb on hs68 cells (fibroblast cell line) was highest in the tests. the mechanism analysis revealed that the photocytotoxicities of led and incandescent lamp were both caused by cell lipid peroxidation. led and incandescent light could promote the production of ros, raise lipid peroxidation level and lower the activity of the antioxidant key enzymes in mammalian cells, and finally cause a number of cells death. however, the negative function of led was significantly smaller than incandescent light and ultraviolet in daily interior lighting condition. and the significantly lower photocytotoxicity of led might be due to the less existence of ultraviolet. therefore, led is an efficient and relative safe light source in interior lighting system, which should be widely used instead of traditional light source. (c) 2012 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics |
| 关键词[WOS] | human skin cells ; oxidative stress ; glutathione disulfide ; lipid-peroxidation ; efficiency ; fibroblasts ; uvb |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312916900002 |
| 公开日期 | 2013-03-15 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3576]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin 300072, Peoples R China 2.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Peoples R China 3.Xiamen Univ, Tan Kah Kee Coll, Zhangzhou 363105, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Jiayin,Gao, Tingting,Ye, Maole,et al. The photocytotoxicity of different lights on mammalian cells in interior lighting system[J]. journal of photochemistry and photobiology b-biology,2012,117:13-18. |
| APA | Song, Jiayin,Gao, Tingting,Ye, Maole,Bi, Hongtao,&Liu, Gang.(2012).The photocytotoxicity of different lights on mammalian cells in interior lighting system.journal of photochemistry and photobiology b-biology,117,13-18. |
| MLA | Song, Jiayin,et al."The photocytotoxicity of different lights on mammalian cells in interior lighting system".journal of photochemistry and photobiology b-biology 117(2012):13-18. |
入库方式： OAI收割
来源：西北高原生物研究所
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