Preparation of a Novel Glucuronomannan from Auricularia auricala and its Immunological Activity
文献类型：期刊论文
| 作者 | Li, Zonghong1; Jiang, Dan1; Bi, Hongtao2; Liu, Dazheng1; Jang, Sungju; Zhou, Yifa1 |
| 刊名 | natural product communications
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 7期号:11页码:1507-1510 |
| 关键词 | Glucuronomannan Auricularia auricala B lymphocyte proliferations Nitric oxide Macrophages |
| ISSN号 | 1934-578x |
| 中文摘要 | a glucuronomannan (aa-4-h, mw around 4 kda) was prepared from the fruit bodies of auricularia auricala by extraction with hot water, deproteination by sevag reagent, stepwise precipitation with ethanol and partial acid hydrolysis. monosaccharides analysis revealed that aa-4-h consisted of 91% mannose (man) and 9% glucuronic acid (glca). ft-ir, nmr and methylation analyses indicated that aa-4-h is a branched glucuronomannan. its main chains are composed of 1, 3-linked alpha-manp, side chains are single alpha-manp or alpha-glca residues attached to the o-2 and o-6 of man residues of the main chains. bioassay indicated that aa-4-h remarkably enhanced b lymphocyte proliferation and increased the production of nitric oxide of macrophages in vitro. thus, glucuronomannan aa-4-h could be explored as a potential immunostimulation agent. |
| 英文摘要 | a glucuronomannan (aa-4-h, mw around 4 kda) was prepared from the fruit bodies of auricularia auricala by extraction with hot water, deproteination by sevag reagent, stepwise precipitation with ethanol and partial acid hydrolysis. monosaccharides analysis revealed that aa-4-h consisted of 91% mannose (man) and 9% glucuronic acid (glca). ft-ir, nmr and methylation analyses indicated that aa-4-h is a branched glucuronomannan. its main chains are composed of 1, 3-linked alpha-manp, side chains are single alpha-manp or alpha-glca residues attached to the o-2 and o-6 of man residues of the main chains. bioassay indicated that aa-4-h remarkably enhanced b lymphocyte proliferation and increased the production of nitric oxide of macrophages in vitro. thus, glucuronomannan aa-4-h could be explored as a potential immunostimulation agent. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; food science & technology |
| 研究领域[WOS] | pharmacology & pharmacy ; food science & technology |
| 关键词[WOS] | mannose receptor ; innate immunity ; judae ; polysaccharides ; macrophages ; ligands ; lectin ; cells |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000311663700024 |
| 公开日期 | 2013-03-15 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3590]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China 2.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zonghong,Jiang, Dan,Bi, Hongtao,et al. Preparation of a Novel Glucuronomannan from Auricularia auricala and its Immunological Activity[J]. natural product communications,2012,7(11):1507-1510. |
| APA | Li, Zonghong,Jiang, Dan,Bi, Hongtao,Liu, Dazheng,Jang, Sungju,&Zhou, Yifa.(2012).Preparation of a Novel Glucuronomannan from Auricularia auricala and its Immunological Activity.natural product communications,7(11),1507-1510. |
| MLA | Li, Zonghong,et al."Preparation of a Novel Glucuronomannan from Auricularia auricala and its Immunological Activity".natural product communications 7.11(2012):1507-1510. |
入库方式： OAI收割
来源：西北高原生物研究所
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