Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats
文献类型：期刊论文
| 作者 | Chen, Fang1; Du, Shouyang1; Bian, Jianghui2; You, Zhi-Bing3; Wu, Yan1 |
| 刊名 | hormones and behavior
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 61期号:4页码:504-511 |
| 关键词 | Corticosterone Gestational hypoxia Maternal behavior Offspring development Rat |
| ISSN号 | 0018-506x |
| 中文摘要 | stress during pregnancy is known to have a significant impact on animal's behavior and offspring development. the effects of gestational hypoxia on maternal behavior have not been studied. in the present study, we investigated the effects of gestational hypoxia exposure on dam's maternal behavior, offspring's growth and plasma corticosterone levels after parturition in rats. altitude hypoxia (3 and 5 km) was simulated in the hypobaric chambers during the last week of pregnancy and the effects were compared to those found in controls exposed at sea level. we found that gestational hypoxia significantly decreased dam's arched-back nursing activity across the lactation period. the effect was more profound in 5 km group. gestational hypoxia also altered other maternal behaviors such as blanket and passive nursing. hypoxia exposure was associated with abnormal birth weight and postnatal growth in pups, with a significantly higher and lower birth weight than control found in 3 and 5 km groups, respectively, and accelerated growth in both stressed groups. gestational hypoxia exposure significantly elevated plasma corticosterone levels in dams at the time of weaning and in pups across the measurement days. taken together, the present results indicate that hypoxia, particularly severe hypoxia during the late phase of pregnancy has a significantly adverse impact on animal's behavior, endocrine function and offspring development the higher birth weight found in the offspring of 3 km group suggests a compensatory system counteracting with the inhibitory effects of hypoxia on fetus growth at this altitude. (c) 2012 elsevier inc. all rights reserved. |
| 英文摘要 | stress during pregnancy is known to have a significant impact on animal's behavior and offspring development. the effects of gestational hypoxia on maternal behavior have not been studied. in the present study, we investigated the effects of gestational hypoxia exposure on dam's maternal behavior, offspring's growth and plasma corticosterone levels after parturition in rats. altitude hypoxia (3 and 5 km) was simulated in the hypobaric chambers during the last week of pregnancy and the effects were compared to those found in controls exposed at sea level. we found that gestational hypoxia significantly decreased dam's arched-back nursing activity across the lactation period. the effect was more profound in 5 km group. gestational hypoxia also altered other maternal behaviors such as blanket and passive nursing. hypoxia exposure was associated with abnormal birth weight and postnatal growth in pups, with a significantly higher and lower birth weight than control found in 3 and 5 km groups, respectively, and accelerated growth in both stressed groups. gestational hypoxia exposure significantly elevated plasma corticosterone levels in dams at the time of weaning and in pups across the measurement days. taken together, the present results indicate that hypoxia, particularly severe hypoxia during the late phase of pregnancy has a significantly adverse impact on animal's behavior, endocrine function and offspring development the higher birth weight found in the offspring of 3 km group suggests a compensatory system counteracting with the inhibitory effects of hypoxia on fetus growth at this altitude. (c) 2012 elsevier inc. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | behavioral sciences ; endocrinology & metabolism |
| 研究领域[WOS] | behavioral sciences ; endocrinology & metabolism |
| 关键词[WOS] | pituitary-adrenal axis ; prenatal stress ; maternal-behavior ; gestational stress ; norway rats ; care ; corticosterone ; insulin ; mice ; hippocampus |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000302763700006 |
| 公开日期 | 2013-03-15 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3694]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Hangzhou Normal Univ, Xiasha High Educ Area, Coll Life & Environm Sci, Hangzhou 310036, Zhejiang, Peoples R China 2.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810008, Qinghai, Peoples R China 3.NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA |
| 推荐引用方式 GB/T 7714 | Chen, Fang,Du, Shouyang,Bian, Jianghui,et al. Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats[J]. hormones and behavior,2012,61(4):504-511. |
| APA | Chen, Fang,Du, Shouyang,Bian, Jianghui,You, Zhi-Bing,&Wu, Yan.(2012).Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats.hormones and behavior,61(4),504-511. |
| MLA | Chen, Fang,et al."Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats".hormones and behavior 61.4(2012):504-511. |
入库方式： OAI收割
来源：西北高原生物研究所
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