HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP
文献类型：期刊论文
| 作者 | Zongbin Cui ; Zuoyan Zhu |
| 刊名 | FISH PHYSIOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 1993 |
| 卷号 | 12期号:2页码:161-169 |
| 关键词 | COMMON CARP CRUCIAN CARP GROWTH HORMONE GROWTH HORMONE GENE TRANSGENIC FISH HORMONAL REPLACEMENT HYPOPHYSECTOMY |
| 中文摘要 | Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 and F2 transgenics. Following hypophysectomy of the transgenic F2 common carp, non-transgenic common carp and non-transgenic crucian carp, growth was monitored for up to 110 days. In addition, recombinant hGH was injected subcutaenously into a group of the non-transgenic crucian carp. Growth rate analyses indicated that (1) hypophysectomy of non-transgenic common carp and crucian carp results in the cessation of growth, (2) hGH administration can stimulate the growth of hypophysectomized crucian carp and (3) hypophysectomized hGH-transgenic common carp continue to grow in the absence of their own growth hormone, suggesting that the hGH-transgene is being expressed in tissues other than the pituitary. |
| 学科主题 | Biochemistry & Molecular Biology; Fisheries; Physiology |
| 收录类别 | SCI |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/10324]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zongbin Cui,Zuoyan Zhu. HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,1993,12(2):161-169. |
| APA | Zongbin Cui,&Zuoyan Zhu.(1993).HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP.FISH PHYSIOLOGY AND BIOCHEMISTRY,12(2),161-169. |
| MLA | Zongbin Cui,et al."HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP".FISH PHYSIOLOGY AND BIOCHEMISTRY 12.2(1993):161-169. |
入库方式： OAI收割
来源：水生生物研究所
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