Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac
文献类型：期刊论文
| 作者 | Wang Q(汪琴)1 ; Wang WB(王文波)1; Wu J(吴洁)2; Wang AQ(王爱勤)1,2; Wang AQ(王爱勤)
|
| 刊名 | Journal of Applied Polymer Science
 |
| 出版日期 | 2012 |
| 卷号 | 124期号:6页码:4424-4432 |
| 关键词 | composite hydrogel carboxymethyl cellulose attapulgite pH-sensitive controlled release |
| ISSN号 | 0021-8995 |
| 通讯作者 | 王爱勤 |
| 英文摘要 | A series of pH-sensitive composite hydrogel beads, carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate (CMC-g-PAA/APT/SA), were prepared by combining CMC-g-PAA/APT composite and SA, using Ca2+ as the ionic crosslinking agent and diclofenac sodium (DS) as the model drug. The effects of APT content and external pH on the swelling properties and release behaviors of DS from the composite hydrogel beads were investigated. The results showed that the composite hydrogel beads exhibited good pH-sensitivity. Introducing 20% APT into CMC-g-PAA hydrogel could change the surface structure of the composite hydrogel beads, decrease the swelling ability, and relieve the burst release effect of DS. The drug cumulative release ratio of DS from the hydrogel beads in simulated gastric fluid was only 3.71% within 3 hour, but in simulated intestinal fluid about 50% for 3 hour, 85% for 12 hour, up to 90% after 24 hour. The obtained results indicated that the CMC-g-PAA/APT/SA hydrogel beads could be applied to the drug delivery system as drug carriers in the intestinal tract. |
| 学科主题 | 环境材料与生态化学 |
| 收录类别 | SCI |
| 资助信息 | Jiangsu Provincial Science and Technology Office; contract grant number: BE2009098;Special Research Fund of Scholarship of Dean of CAS. |
| 语种 | 英语 |
| WOS记录号 | WOS:000301224500003 |
| 公开日期 | 2013-03-24 |
| 源URL | [http://210.77.64.217/handle/362003/2532]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 通讯作者 | Wang AQ(王爱勤) |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Huaiyin Inst Technol, Key Lab Attapulgite Sci & Appl Technol Jiangsu Pr, Huaian 223003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Q,Wang WB,Wu J,et al. Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac[J]. Journal of Applied Polymer Science,2012,124(6):4424-4432. |
| APA | Wang Q,Wang WB,Wu J,Wang AQ,&王爱勤.(2012).Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac.Journal of Applied Polymer Science,124(6),4424-4432. |
| MLA | Wang Q,et al."Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac".Journal of Applied Polymer Science 124.6(2012):4424-4432. |
入库方式： OAI收割
来源：兰州化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。