Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels
文献类型：期刊论文
| 作者 | Sun JS ; Liu C(刘超); Li MM; Wang JD; Xianyu YL; Hu GQ(胡国庆); Jiang XY
|
| 刊名 | BIOMICROFLUIDICS
 |
| 出版日期 | 2013-02-04 |
| 卷号 | 7期号:1页码:011802/1-011802/11 |
| 通讯作者邮箱 | guoqing.hu@imech.ac.cn; xingyujiang@nanoctr.cn |
| 关键词 | bioMEMS cellular biophysics hydrodynamics microchannel flow tumours |
| ISSN号 | 1932-1058 |
| 产权排序 | [Sun, Jiashu; Li, Mengmeng; Wang, Jidong; Xianyu, Yunlei; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Hu, Guoqing] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China |
| 通讯作者 | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China. |
| 合作状况 | 国内 |
| 中文摘要 | In this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-mu m-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 x 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 x diluted blood cells was also achieved by the double spiral channel. |
| 学科主题 | 微机电系统中的流体力学问题 |
| 分类号 | 一类 |
| 收录类别 | SCI ; EI |
| 资助信息 | MOST [2011CB933201, 2009CB930001, 2011CB707604]; NSFC [51105086, 21025520, 90813032, 50890182]; CAS [KJCX2-YW-M15, KJCX2-YW-H18] |
| 原文出处 | http://dx.doi.org/10.1063/1.4774311 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315597100008 |
| 公开日期 | 2013-04-01 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/47122]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun JS,Liu C,Li MM,et al. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels[J]. BIOMICROFLUIDICS,2013,7(1):011802/1-011802/11. |
| APA | Sun JS.,刘超.,Li MM.,Wang JD.,Xianyu YL.,...&Jiang XY.(2013).Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.BIOMICROFLUIDICS,7(1),011802/1-011802/11. |
| MLA | Sun JS,et al."Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels".BIOMICROFLUIDICS 7.1(2013):011802/1-011802/11. |
入库方式： OAI收割
来源：力学研究所
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