Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging
文献类型：期刊论文
| 作者 | Niu DC(牛德超) ; Liu XH(刘晓航) ; Li YS(李永生) ; Ma Z(马志) ; Dong WJ(董文杰) ; Chang S(常舒) ; Zhao WR(赵文茹) ; Gu JL(顾金楼) ; Zhang SJ(张胜建) ; Shi JL(施剑林) |
| 刊名 | J. Mater. Chem.
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:36页码:13825-13831 |
| ISSN号 | 0959-9428 |
| 其他题名 | 用于磁共振显像的、生物相容性和多功能的PCL-b-PAA共聚物均一杂化胶束的制备 |
| 通讯作者 | 李永生 |
| 英文摘要 | In this paper, a simple strategy was developed to fabricate a novel kind of uniform, biocompatible and PEGylated multifunctional hybrid micelles with multiple magnetite nanocrystal loaded cores and dye-doped silica cross-linked shells based on the self-assembly between poly(epsilon-caprolactone)-b-poly(acrylic acid) copolymer and inorganic nanoparticles. The loading of multiple magnetite nanoparticles in the core part of the hybrid micelles endows them with T2-weighted MR imaging functionalities. Small dye molecules (Rhodamine B) were directly incorporated into the silica layer framework during the cross-linking process, imparting the hybrid micelles with fluorescent imaging modality. Poly(ethylene glycol) (PEG) was grafted to reduce the phagocytic capture of nanoparticles by cellular components of the immune system. Importantly, the potential application of magnetite incorporated PEGylated hybrid micelles as T2 contrast agents for MRI was demonstrated both in vitro and in vivo, with the passive targeting behavior via EPR effect due to the leaky vasculature and poor lymphatic drainage in tumors. |
| 学科主题 | 高分子化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1039/c1jm10929d |
| 语种 | 英语 |
| WOS记录号 | WOS:000294441300016 |
| 公开日期 | 2013-04-11 |
| 源URL | [http://202.127.28.38/handle/331003/25409]  |
| 专题 | 上海有机化学研究所_分析化学研究室 |
| 推荐引用方式 GB/T 7714 | Niu DC,Liu XH,Li YS,et al. Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging[J]. J. Mater. Chem.,2011,21(36):13825-13831. |
| APA | 牛德超.,刘晓航.,李永生.,马志.,董文杰.,...&施剑林.(2011).Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging.J. Mater. Chem.,21(36),13825-13831. |
| MLA | 牛德超,et al."Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging".J. Mater. Chem. 21.36(2011):13825-13831. |
入库方式： OAI收割
来源：上海有机化学研究所
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