The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy
文献类型：期刊论文
| 作者 | Xiao HH ; Song HQ ; Zhang Y ; Qi RG ; Wang R ; Xie ZG ; Huang YB ; Li YX ; Wu Y ; Jing XB |
| 刊名 | biomaterials
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:33页码:8657-8669 |
| 关键词 | CONFORMATIONAL-CHANGES BIS(PLATINUM) COMPLEXES BIODEGRADABLE POLYMER ANTICANCER AGENTS DNA-BINDING PHASE-I TRINUCLEAR CARBOXYLATION CISPLATIN(IV) CYTOTOXICITY |
| ISSN号 | 0142-9612 |
| 通讯作者 | jing xb |
| 中文摘要 | two dinuclear platinum(iv) prodrugs were prepared from cisplatin and oxaliplatin, and tethered to amphiphilic biodegradable block copolymers. the polymeric dinuclear platinum(iv) prodrugs were allowed to self-assemble into nanomicelles, which showed reduced systemic toxicity, relatively long blood circulation, and enhanced antitumor efficacy. in this way, the bottleneck of present multinuclear platinum drugs, especially their severe systemic toxicity, might be overcome. (c) 2012 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310401000044 |
| 公开日期 | 2013-04-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47874]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao HH,Song HQ,Zhang Y,et al. The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy[J]. biomaterials,2012,33(33):8657-8669. |
| APA | Xiao HH.,Song HQ.,Zhang Y.,Qi RG.,Wang R.,...&Jing XB.(2012).The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy.biomaterials,33(33),8657-8669. |
| MLA | Xiao HH,et al."The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy".biomaterials 33.33(2012):8657-8669. |
入库方式： OAI收割
来源：长春应用化学研究所
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