Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers
文献类型：期刊论文
| 作者 | Song WT ; Li MQ ; Tang ZH ; Li QS ; Yang Y ; Liu HY ; Duan TC ; Hong H ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:11页码:1514-1523 |
| 关键词 | DRUG-DELIVERY IN-VIVO PLATINUM COMPLEXES POLYMERIC MICELLES ANTITUMOR-ACTIVITY TARGETED DELIVERY BLOCK-COPOLYMER NANOPARTICLES PACLITAXEL THERAPY |
| ISSN号 | 1616-5187 |
| 通讯作者 | hong h |
| 中文摘要 | cddp is loaded into methoxypoly(ethylene glycol)-block-poly(l-glutamic acid) (mpeg-b-plg), and a combination with irgd is applied for nsclc chemotherapy. the cddp-loaded micelles show sustained cisplatin release in pbs, dose- and time-dependent inhibition to hela and a549 cell proliferation, and no apparent hemolysis activities. in in vivo studies using subcutaneous nsclc xenograft models (a549), both free cddp and cddp-loaded micelles show an evident anti-tumor effect. however, the toxicity of cddp is significantly reduced in the cases of cddp-loaded micelles and co-administration with irgd, and the survival time is prolonged by over 30%. therefore, mpeg-b-plg-loaded cisplatin and the combination with irgd provides a promising new therapy for nsclc. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310601500009 |
| 公开日期 | 2013-04-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47876]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song WT,Li MQ,Tang ZH,et al. Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers[J]. macromolecular bioscience,2012,12(11):1514-1523. |
| APA | Song WT.,Li MQ.,Tang ZH.,Li QS.,Yang Y.,...&Chen XS.(2012).Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers.macromolecular bioscience,12(11),1514-1523. |
| MLA | Song WT,et al."Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers".macromolecular bioscience 12.11(2012):1514-1523. |
入库方式： OAI收割
来源：长春应用化学研究所
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