Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Niu J ; Pi ZF ; Yue H ; Wang Y ; Yu Q ; Liu SY |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2012 |
| 卷号 | 907页码:7-12 |
| 关键词 | ACTIVATED RECEPTOR-ALPHA LIVER-GLYCOGEN STREPTOZOTOCIN METABONOMICS METABOLITES EXTRACT INSULIN REPAIR |
| ISSN号 | 1570-0232 |
| 通讯作者 | liu sy |
| 中文摘要 | ginseng polysaccharide is known to have anti-hyperglycemic and anti-hyperlipidemic effects in vivo and its precise mechanism of action is not clear. a urinary metabolomics method based on rapid-resolution liquid chromatography/mass spectrometry (rrlc/ms) was developed to investigate the effect of water-soluble ginseng polysaccharide (wgp) on type 2 diabetes in rats. principal component analysis (pca) was carried out for pattern recognition and a clear separation between type 2 diabetic rats and those treated with wgp was achieved. eight potential biomarkers were found and identified. significantly increased inosine, serotonin, phenylpropionylglycine and dodecanedioic acid showed the effect of wgp on purine metabolism, tryptophan metabolism, fatty acid metabolism and energy metabolism. 1-methyladenine, 4-deoxyerythronic acid, 5-hydroxyhexanoic acid and tetrahydrocortisol were significantly decreased which indicated that wgp can regulate dna metabolism, organic acids metabolism and steroid hormone metabolism. this work is helpful in the effect mechanism study of ginseng polysaccharide. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310256500002 |
| 公开日期 | 2013-04-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47896]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Niu J,Pi ZF,Yue H,et al. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2012,907:7-12. |
| APA | Niu J,Pi ZF,Yue H,Wang Y,Yu Q,&Liu SY.(2012).Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,907,7-12. |
| MLA | Niu J,et al."Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 907(2012):7-12. |
入库方式： OAI收割
来源：长春应用化学研究所
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