Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery
文献类型：期刊论文
| 作者 | Song WT ; Tang ZH ; Li MQ ; Lv SX ; Yu HY ; Ma LL ; Zhuang XL ; Huang YB ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:10页码:1375-1383 |
| 关键词 | BLOCK-COPOLYMER MICELLES IN-VITRO EVALUATION CANCER-THERAPY POLYMERIC MICELLES EXTRACELLULAR PH SIDE-CHAINS DOXORUBICIN TUMOR NANOGELS RELEASE |
| ISSN号 | 1616-5187 |
| 通讯作者 | chen xs |
| 中文摘要 | the ph sensitivity of a series of pbaes synthesized from primary amines and diacrylates is studied. by changing alkyl groups of the amine monomers, the pkb can be tuned across a broad range (from 3.5 to 7.2). micelles formed from a peg-pbae block copolymer retain the ph sensitivity of pbae and can stably load hydrophobic molecules under neutral ph, while quickly dissociate and release their cargoes at ph similar to 6.0. when the chemotherapy drug dox is loaded, the micelles show efficient cell proliferation inhibition to hela cells and fast intracellular release. thus, the primary-amine-based pbaes are shown to be promising in the construction of intracellular targeting drug delivery systems. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000309676400011 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47917]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song WT,Tang ZH,Li MQ,et al. Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery[J]. macromolecular bioscience,2012,12(10):1375-1383. |
| APA | Song WT.,Tang ZH.,Li MQ.,Lv SX.,Yu HY.,...&Chen XS.(2012).Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery.macromolecular bioscience,12(10),1375-1383. |
| MLA | Song WT,et al."Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery".macromolecular bioscience 12.10(2012):1375-1383. |
入库方式： OAI收割
来源：长春应用化学研究所
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