Perylene ligand wrapping G-quadruplex DNA for label-free fluorescence potassium recognition
文献类型：期刊论文
| 作者 | Hu YW ; Han DX ; Zhang QX ; Wu TS ; Li FH ; Niu L |
| 刊名 | biosensors & bioelectronics
 |
| 出版日期 | 2012 |
| 卷号 | 38期号:1页码:396-401 |
| 关键词 | 3 4 ENERGY-TRANSFER 9 CONJUGATED POLYMER 10-PERYLENETETRACARBOXYLIC ACID DIIMIDES SIDE-CHAINS ION OLIGONUCLEOTIDE AGGREGATION SELECTIVITY COMPLEX BINDING |
| ISSN号 | 0956-5663 |
| 通讯作者 | niu l |
| 中文摘要 | a perylene ligand, n,n-bis-(1-aminopropyl-3-propylimidazol salt)-3,4,9,10-perylene tetracarboxylic acid diimide ligand (pdi), which consisted of pi-conjugated perylene moiety and hydrophilic side chains with positively charged imidazole rings, was used to wrap g-quadruplex for fluorescence turn-on k+ recognition. electrostatic attraction between pdi's positively charged imidazole rings and dna's negatively charged phosphate backbones enabled pdi to accumulate on dna. upon trapping k+, these g-rich dna sequences transitioned to g-quadruplex. subsequently, pdi ligands wrapped g-quadruplex, in which the flat aromatic core of pdi ligand interacted with g-quartet through pi-pi stacking and the side chains were positioned in grooves through electrostatic interactions. consequently, the interaction mode change and conformational transition from pdi stacked g-sequence to pdi wrapped g-quadruplex led to pdi fluorescence enhancement, which was readily monitored as the detection signal. this strategy excluded the sequence tagging step and exhibited high selectivity and sensitivity towards k+ ion with the linear detection range of 10-150 nm. besides. pdi ligands may hold diagnostic and therapeutic application potentials to human telomere and cancer cells. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000308455700062 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47925]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu YW,Han DX,Zhang QX,et al. Perylene ligand wrapping G-quadruplex DNA for label-free fluorescence potassium recognition[J]. biosensors & bioelectronics,2012,38(1):396-401. |
| APA | Hu YW,Han DX,Zhang QX,Wu TS,Li FH,&Niu L.(2012).Perylene ligand wrapping G-quadruplex DNA for label-free fluorescence potassium recognition.biosensors & bioelectronics,38(1),396-401. |
| MLA | Hu YW,et al."Perylene ligand wrapping G-quadruplex DNA for label-free fluorescence potassium recognition".biosensors & bioelectronics 38.1(2012):396-401. |
入库方式： OAI收割
来源：长春应用化学研究所
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