Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier
文献类型：期刊论文
| 作者 | Yue J ; Liu S ; Wang R ; Hu XL ; Xie ZG ; Huang YB ; Jing XB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:9页码:1209-1219 |
| 关键词 | AMPHIPHILIC BLOCK-COPOLYMERS DRUG-DELIVERY TRANSFERRIN RECEPTOR MONOCLONAL-ANTIBODY GENE-EXPRESSION P-GLYCOPROTEIN CANCER-THERAPY NANOPARTICLES TRANSPORTERS TUMORS |
| ISSN号 | 1616-5187 |
| 通讯作者 | jing xb |
| 中文摘要 | multifunctional hybrid micelles are prepared from amphiphilic mal-peg-b-pla and mpeg-b-p(la-co-dhc/rhb) block copolymers. a specific anti-transferrin receptor antibody, ox26, is linked onto the surface of the micelles. elisa indicates that the conjugated antibody preserves its activity. ox26 conjugation can increase the uptake efficiency of micelles by target cell lines (c6). pharmacokinetics and in vivo biodistribution experiments are carried out to investigate the ability of ox26-conjugated micelles (immunomicelles) to cross the bloodbrain barrier. the data show that the brain uptake of ox26-conjugated micelles is much more than that of ox26-free ones. therefore, ox26-conjugated micelles will be promising drug carriers to cross the blood-brain barrier. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000308393100008 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47964]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yue J,Liu S,Wang R,et al. Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier[J]. macromolecular bioscience,2012,12(9):1209-1219. |
| APA | Yue J.,Liu S.,Wang R.,Hu XL.,Xie ZG.,...&Jing XB.(2012).Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier.macromolecular bioscience,12(9),1209-1219. |
| MLA | Yue J,et al."Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier".macromolecular bioscience 12.9(2012):1209-1219. |
入库方式： OAI收割
来源：长春应用化学研究所
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