Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery
文献类型：期刊论文
| 作者 | Kuang HH ; Wu SH ; Xie ZG ; Meng FB ; Jing XB ; Huang YB |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:9页码:3004-3012 |
| 关键词 | MOLECULAR RECOGNITION HYDROGEN-BONDS DIBLOCK COPOLYMERS BLOCK-COPOLYMERS SDS MICELLES POLYMER DOXORUBICIN VESICLES SOLVENTS BEHAVIOR |
| ISSN号 | 1525-7797 |
| 通讯作者 | meng fb |
| 中文摘要 | biodegradable nucleobase-grafted amphiphilic copolymer, the methoxyl poly (ethylene glycol)-b-poly (l-lactide-omega-2-methyl-2(3-(2,3-dihydroxylpropylthio) propyloxycarbonyl)-propylene carbonate/1-carboxymethylthymine) (mpeg-b- p(la-co-mpt)), was synthesized. h-1 nmr titration and ft-ir spectroscopy indicated that the hydrogen-bonding could be formed between mpeg-b-p(la-co-mpt) and 9-hexadecyladenine (a-c16). the hydrophobic microenvironment of the amphiphilic copolymer can protect the complementary multiple hydrogen bonds between mpeg-b-p(la-co-mpt) and a-c16 from water effectively. the addition of a-c16 not only lowered the critical aggregation concentration (cac) of mpeg-b-p(la-co-mpt)/a-c16 nanoparticles (nps) in aqueous solution but also induced different morphologies, which can be observed by transmission electron microscopy (tem). meanwhile, dynamic light scattering (dls) and turbidometry was utilized to evaluate the effect of temperature and ph change on the stability of mpeg-b-p(la-co-mpt)/a-c16 nps. cytotoxicity evaluation showed good biocompatibility of the mpeg-b-p(la-co-mpt)/a-c16 nps. the in vitro drug release profile showed that with the increase of a-c16 content, the doxorubiucin (dox) release at ph 7.4 decreased, while the faster release rate was observed with the addition of a-c16 with a ph of 5.0. importantly, dox-loaded nps exerted comparable cytotoxicity against mda-mb-231 cells. this work provided a new method to stabilize np structure using hydrogen-bonds and would have the potential to be applied in controlled drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000308508500044 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/47971]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kuang HH,Wu SH,Xie ZG,et al. Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery[J]. biomacromolecules,2012,13(9):3004-3012. |
| APA | Kuang HH,Wu SH,Xie ZG,Meng FB,Jing XB,&Huang YB.(2012).Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery.biomacromolecules,13(9),3004-3012. |
| MLA | Kuang HH,et al."Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery".biomacromolecules 13.9(2012):3004-3012. |
入库方式： OAI收割
来源：长春应用化学研究所
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