Fabrication of a sensor chip containing Au and Ag electrodes and its application for sensitive Hg(II) determination using chronocoulometry
文献类型：期刊论文
| 作者 | Chen CG ; Du Y ; Li J ; Yang XR ; Wang EK |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2012 |
| 卷号 | 738页码:45-50 |
| 关键词 | BASE-PAIRS HG-II DNA GOLD |
| ISSN号 | 0003-2670 |
| 通讯作者 | wang ek |
| 中文摘要 | in this work, we explored a novel fabrication method to construct au and ag electrodes on chip, utilizing the different solubility of gold and silver in different etching solutions. ki-i-2 etching solution and 50% hno3 were chosen to dissolve the metal layers alternatively. planar electrodes with gold and silver could be simultaneously and accurately patterned on chip using photolithographic technique. the as-prepared electrode could be directly served as integrated three-electrode system for electrochemical measurement. based on it, a sensing strategy has been carried out using home-made electrochemical sensing (ecs) chip, which depended on the competition of double strand dna and hg(ii)-mediated t-t base pairs (t-hg(ii)-t). actually, a mercury specific oligonucleotide (mso) was immobilized onto the thus-fabricated gold working electrode and employed as the sensing element. chronocoulometry (cc) was chosen to monitor the differences of surface charge volume and quantify the concentrations of hg(ii) ions with a low detection limit down to 1 nm. therefore, a facile method to fabricate au and ag electrodes has been demonstrated to simplify the production of ecs chip. the ecs chip was finally used for constructing an effective sensing platform for sensitive hg(ii) determination, which held promising potential for designing ecs chip in lab-on-a-chip device or point-of-care diagnosis. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306877800006 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48008]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen CG,Du Y,Li J,et al. Fabrication of a sensor chip containing Au and Ag electrodes and its application for sensitive Hg(II) determination using chronocoulometry[J]. analytica chimica acta,2012,738:45-50. |
| APA | Chen CG,Du Y,Li J,Yang XR,&Wang EK.(2012).Fabrication of a sensor chip containing Au and Ag electrodes and its application for sensitive Hg(II) determination using chronocoulometry.analytica chimica acta,738,45-50. |
| MLA | Chen CG,et al."Fabrication of a sensor chip containing Au and Ag electrodes and its application for sensitive Hg(II) determination using chronocoulometry".analytica chimica acta 738(2012):45-50. |
入库方式： OAI收割
来源：长春应用化学研究所
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