Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection
文献类型：期刊论文
| 作者 | Wang L ; Zhu JB ; Han L ; Jin LH ; Zhu CZ ; Wang EK ; Dong SJ |
| 刊名 | acs nano
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:8页码:6659-6666 |
| 关键词 | LABEL-FREE GOLD NANOPARTICLES THROMBIN DETECTION MAGNETIC BEADS DNA APTAMER SELECTION OXIDE ENRICHMENT MOLECULES ADENOSINE |
| ISSN号 | 1936-0851 |
| 通讯作者 | wang ek |
| 中文摘要 | in this work, a go/aptamer system was constructed to create multiplex logic operations and enable sensing of multiplex targets. 6-carboxy-fluorescein (fam)-labeled adenosine triphosphate binding aptamer (aba) and fam-labeled thrombin binding aptamer (tba) were first adsorbed onto graphene oxide (go) to form a go/aptamer complex, leading to the quenching of the fluorescence of fam. we demonstrated that the unique go/aptamer interaction and the specific aptamer target recognition in the target/go/aptamer system were programmable and could be utilized to regulate the fluorescence of fam via or and inhibit logic gates. the fluorescence changed according to different input combinations, and the integration of or and inhibit logic gates provided an interesting approach for logic sensing applications where multiple target molecules were present. high-throughput fluorescence imagings that enabled the simultaneous processing of many samples by using the combinatorial logic gates were realized. the developed logic gates may find applications in further development of dna circuits and advanced sensors for the identification of multiple targets in complex chemical environments. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000307988900017 |
| 公开日期 | 2013-04-23 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48016]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang L,Zhu JB,Han L,et al. Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection[J]. acs nano,2012,6(8):6659-6666. |
| APA | Wang L.,Zhu JB.,Han L.,Jin LH.,Zhu CZ.,...&Dong SJ.(2012).Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection.acs nano,6(8),6659-6666. |
| MLA | Wang L,et al."Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection".acs nano 6.8(2012):6659-6666. |
入库方式： OAI收割
来源：长春应用化学研究所
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