Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings
文献类型：期刊论文
| 作者 | Guocheng Wang ; Liu XY(刘宣勇) ; Hala Zreiqat ; Ding CX(丁传贤) |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES B: Biointerfaces
 |
| 出版日期 | 2011-08-12 |
| 卷号 | 86期号:2页码:267-274 |
| ISSN号 | 0927-7765 |
| 其他题名 | Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings |
| 通讯作者 | 刘宣勇 |
| 中文摘要 | Implant surface topography is one of the most important factors affecting the rate and extent of osseointegration. Randomly micron-roughened surfaces have been documented to support osteoblast adhesion, differentiation, and mineralized phenotype, and thus favoring bone fixation of implants to host tissues. However, few studies have been done yet to investigate whether their effects on osteoblast behaviors can be enhanced by incorporation of nano-scale topographic cues. To validate this hypothesis, zirconia coatings with micron roughness (about 6.6 m) superimposed by nano-sized grains (<50 nm) were fabricated by plasma spraying. To validate the impact of nano-sized grains, post-treatments of surface polishing (SP) and heat treatment (HT) were performed on the as-sprayed (AS) coatings to change the surface topographies but keep the chemical and phase composition similar. Results of in vitro bioactivity test showed that apatite was formed only on coating surfaces with nano-sized grains (AS coatings), indicating the significance of nano-topographic cues on the in vitro bioactivity. Enhanced osteoblast adhesion and higher cell proliferation rate were observed on coatings with both micron-roughness and nano-sized grains (AS-coatings), compared to coatings with smooth surfaces (SP-coatings) and coatings with only micron-scale roughness (heat-treated coatings), indicating the significant effects of nano-size grains on osteoblast responses. As the micron rough surfaces have been well-documented to enhance bone fixation, results of this work suggest that a combination of surface modifications at both micron and nano-scale is required for enhanced osseointegration of orthopedic implants. |
| 学科主题 | 生物材料 |
| 收录类别 | SCI收录 |
| WOS记录号 | WOS:000292226800003 |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/962]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guocheng Wang,Liu XY,Hala Zreiqat,et al. Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings[J]. COLLOIDS AND SURFACES B-BIOINTERFACES B: Biointerfaces,2011,86(2):267-274. |
| APA | Guocheng Wang,刘宣勇,Hala Zreiqat,&丁传贤.(2011).Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings.COLLOIDS AND SURFACES B-BIOINTERFACES B: Biointerfaces,86(2),267-274. |
| MLA | Guocheng Wang,et al."Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings".COLLOIDS AND SURFACES B-BIOINTERFACES B: Biointerfaces 86.2(2011):267-274. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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