BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE
文献类型：期刊论文
| 作者 | Li C ; Zhang Z ; He CL ; Zhuang XL ; Chen L ; Cai Q ; Xue Y ; Zhang B ; Wang SZ ; Meng WY ; Chen XS |
| 刊名 | acta polymerica sinica
 |
| 出版日期 | 2012 |
| 期号 | 7页码:778-783 |
| 关键词 | PH-SENSITIVE HYDROGELS BEHAVIOR RELEASE PROTEIN SYSTEM |
| ISSN号 | 1000-3304 |
| 通讯作者 | li c |
| 中文摘要 | a series of thermo-sensitive hydrogels were designed and synthesized via radical polymerization of n-isopropylacrylamide (nipaam) by using a biodegradable acryloyl-poly (epsilon-caprolactone)-2-hydroxylethyl methacrylate (ac-pcl-hema) as a cross-linker. the influence of temperature on the equilibrium swelling ratio and the optical transmittance of the hydrogel was studied. the in vitro release of parathyroid hormone related peptide (pthrp) which can increase the number and viability of osteoblasts and promote bone formation, from the hydrogel was investigated. the release profiles indicated that the sustained release of pthrp from the smart hydrogel was over 13 days,indicating that the materials have potential applications in the field of oral implantology. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000306532800014 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48038]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li C,Zhang Z,He CL,et al. BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE[J]. acta polymerica sinica,2012(7):778-783. |
| APA | Li C.,Zhang Z.,He CL.,Zhuang XL.,Chen L.,...&Chen XS.(2012).BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE.acta polymerica sinica(7),778-783. |
| MLA | Li C,et al."BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE".acta polymerica sinica .7(2012):778-783. |
入库方式： OAI收割
来源：长春应用化学研究所
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