A Study of Interaction between Flavonoids and the Parallel Quadruplex Structure [d(TGGGGT)]4 by Electrospray Ionization Mass Spectrometry
文献类型：期刊论文
| 作者 | Xu NS ; Yang HM ; Cui M ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | chinese journal of chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 30期号:7页码:1433-1438 |
| 关键词 | POTENT TELOMERASE INHIBITOR CRYSTAL-STRUCTURE STRANDED TETRAPLEX NATURAL-PRODUCTS PROSTATE-CANCER DNA-BINDING GENISTEIN SEQUENCE ANTHRACYCLINES TELOMESTATIN |
| ISSN号 | 1001-604x |
| 通讯作者 | liu sy |
| 中文摘要 | in this study, electrospray ionization mass spectrometry (esi-ms) was used to investigate interaction of 21 flavonoids (10 aglycones and 11 glycosides) with the parallel quadruplex structure [d(tggggt)]4. relative binding affinities of flavonoids toward [d(tggggt)]4 were estimated based on the fraction of bound dna. it was found that [d(tggggt)]4 showed a binding preference to the flavonoid glycosides over flavonoid aglycones. it was deduced that glycosylation played a key role for the [d(tggggt)]4-binding properties of flavonoid glycosides. upon collision-induced dissociation, complexes of flavonoid/[d(tggggt)]4 underwent the loss of flavonoids, suggesting an end-stacking binding mode. the current work demonstrates that esi-ms is a powerful tool in the study of interaction between drugs and nucleic acids. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306562300011 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48067]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu NS,Yang HM,Cui M,et al. A Study of Interaction between Flavonoids and the Parallel Quadruplex Structure [d(TGGGGT)]4 by Electrospray Ionization Mass Spectrometry[J]. chinese journal of chemistry,2012,30(7):1433-1438. |
| APA | Xu NS,Yang HM,Cui M,Song FR,Liu ZQ,&Liu SY.(2012).A Study of Interaction between Flavonoids and the Parallel Quadruplex Structure [d(TGGGGT)]4 by Electrospray Ionization Mass Spectrometry.chinese journal of chemistry,30(7),1433-1438. |
| MLA | Xu NS,et al."A Study of Interaction between Flavonoids and the Parallel Quadruplex Structure [d(TGGGGT)]4 by Electrospray Ionization Mass Spectrometry".chinese journal of chemistry 30.7(2012):1433-1438. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。