Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation
文献类型：期刊论文
| 作者 | Cheng YL ; He CL ; Xiao CS ; Ding JX ; Zhuang XL ; Huang YB ; Chen XS |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:7页码:2053-2059 |
| 关键词 | BLOCK-COPOLYMER HYDROGELS DRUG-DELIVERY SYSTEMS AQUEOUS-SOLUTIONS MULTIBLOCK COPOLYMERS TEMPERATURE ACID) SPECTROSCOPY PEPTIDES SOL PH |
| ISSN号 | 1525-7797 |
| 通讯作者 | chen xs |
| 中文摘要 | thermosensitive hydrogels based on peg and poly(l-glutamate)s bearing different hydrophobic side groups were separately synthesized by the ring-opening polymerization (rop) of l-glutamate n-carboxyanhydrides containing different alkyl protected groups, that is, methyl, ethyl, n-propyl, and n-butyl, using mpeg(45)-nh2 as macroinitiator. the resulting copolymers underwent sol gel transitions in response to temperature change. interestingly, the polypeptides containing methyl and ethyl showed significantly lower critical gelation temperatures (cgts) than those bearing n-propyl and butyl side groups. based on the analysis of c-13 nmr spectra, dls, circular dichroism spectra, and atr-ftir spectra, the sol gel transition mechanism was attributed to the dehydration of poly(ethylene glycol) and the increase of beta-sheet conformation content in the polypeptides. the in vivo gelation test indicated that the copolymer solution (6.0 wt %) immediately changed to a gel after subcutaneous injection into rats. the mass loss of the hydrogel in vitro was accelerated in the presence of proteinase k, and the mtt assay revealed that the block copolymers exhibited no detectable cytotoxicity. the present work revealed that subtle variation in the length of a hydrophobic side group displayed the decisive effect on the gelation behavior of the polypeptides. in addition, the thermosensitive hydrogels could be promising materials for biomedical applications due to their good biocompatibility, biodegradability, and the fast in situ gelation behavior. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306151700009 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48069]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cheng YL,He CL,Xiao CS,et al. Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation[J]. biomacromolecules,2012,13(7):2053-2059. |
| APA | Cheng YL.,He CL.,Xiao CS.,Ding JX.,Zhuang XL.,...&Chen XS.(2012).Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation.biomacromolecules,13(7),2053-2059. |
| MLA | Cheng YL,et al."Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation".biomacromolecules 13.7(2012):2053-2059. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。