Transferrin-Conjugated Micelles: Enhanced Accumulation and Antitumor Effect for Transferrin-Receptor-Overexpressing Cancer Models
文献类型：期刊论文
| 作者 | Yue J ; Liu S ; Wang R ; Hu XL ; Xie ZG ; Huang YB ; Jing XB |
| 刊名 | molecular pharmaceutics
 |
| 出版日期 | 2012 |
| 卷号 | 9期号:7页码:1919-1931 |
| 关键词 | BLOOD-BRAIN-BARRIER AMPHIPHILIC BLOCK-COPOLYMERS ANTICANCER DRUG-DELIVERY PEG-PLA NANOPARTICLES IN-VITRO MEDIATED ENDOCYTOSIS DOXORUBICIN DELIVERY TARGETED DELIVERY TUMOR PACLITAXEL |
| ISSN号 | 1543-8384 |
| 通讯作者 | jing xb |
| 中文摘要 | as the transport protein for iron, transferrin can trigger cellular endocytosis once binding to its receptor (tfr) on the cell membrane. using this property, we conjugated transferrin onto the surface of biodegradable polymeric micelles constructed from amphiphilic block copolymers. the core of micelle was either labeled with a near-infrared dye (nir) or conjugated with a chemotherapeutic drug paclitaxel (ptx) to study the biodistribution or antitumor effect in nude mice bearing subcutaneous tfr-overexpressing cancers. dls and tem showed that the sizes of tf-conjugated and tf-free micelles were in the range of 85-110 nm. confocal laser scanning microscopy and flow cytometry experiments indicated that the uptake efficiency of the micelles by the tfr-overexpressing cells was enhanced by tf conjugation. semiquantitative analysis of the nir signals collected from the tumor site showed that the maximum accumulation was achieved at 28 h in the m(nir) group, while at 22 h in tf-m(nir) groups; and the area under the intensity curve in the tf-m(nir) groups was more than that in m(nir) group. finally, the tumor inhibition effects of targeting micelles were studied with the gastric carcinoma model which overexpressed tfr. the analysis of tumor volumes and the observation of h&e-stained tumor sections showed that tf-m(ptx) had the best antitumor effect compared with the control groups (saline, ptx, and m(ptx)). the results of this study demonstrated the potential application of tf-conjugated polymeric micelles in the treatment of tfr-overexpressing cancers. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305917600007 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48072]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yue J,Liu S,Wang R,et al. Transferrin-Conjugated Micelles: Enhanced Accumulation and Antitumor Effect for Transferrin-Receptor-Overexpressing Cancer Models[J]. molecular pharmaceutics,2012,9(7):1919-1931. |
| APA | Yue J.,Liu S.,Wang R.,Hu XL.,Xie ZG.,...&Jing XB.(2012).Transferrin-Conjugated Micelles: Enhanced Accumulation and Antitumor Effect for Transferrin-Receptor-Overexpressing Cancer Models.molecular pharmaceutics,9(7),1919-1931. |
| MLA | Yue J,et al."Transferrin-Conjugated Micelles: Enhanced Accumulation and Antitumor Effect for Transferrin-Receptor-Overexpressing Cancer Models".molecular pharmaceutics 9.7(2012):1919-1931. |
入库方式： OAI收割
来源：长春应用化学研究所
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