Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption
文献类型：期刊论文
| 作者 | Huang SS ; Li CX ; Cheng ZY ; Fan Y ; Yang PP ; Zhang CM ; Yang KY ; Lin J |
| 刊名 | journal of colloid and interface science
 |
| 出版日期 | 2012 |
| 卷号 | 376页码:312-321 |
| 关键词 | ORDERED MESOPOROUS SILICA CONTROLLED-RELEASE PORE-SIZE FUNCTIONALIZED SBA-15 ENZYME IMMOBILIZATION MOLECULAR-SIEVES FACILE SYNTHESIS CYTOCHROME-C ADSORPTION SPHERES |
| ISSN号 | 0021-9797 |
| 通讯作者 | lin j |
| 中文摘要 | magnetic fe3o4@mesoporous silica (ms) composites were synthesized by generating fe3o4 nanoparticles in the mesoporous silica matrix using the sol-gel method in nitrogen atmosphere. the mesoporous silica hosts include sba-15 particles owning highly ordered p6mm mesostructure, siliceous mesostructured cellular foams (mcfs), and fiber-like mesoporous silica (fms) with unique pore structures. the x-ray diffraction (xrd), transmission electron microscopy (tem), and n-2 adsorption/desorption results show that fe3o4 functionalized mcfs and fms possess suitable mesoporous structure for the adsorption of both small-molecular drug and large biomolecules. the biocompatibility tests on l929 fibroblast cells using mtt assay reveal low cytotoxicity of these systems. these fe3o4@mesoporous silica composites show sustained release properties for aspirin in vitro. the release of the aspirin molecules from the pores of the fe3o4@mesoporous silica composites is basically a diffusive process. fe3o4@mcfs and fe3o4@fms owning larger pore size are good candidates for the adsorption of bovine serum albumin (bsa). these magnetic composites can be potential vectors for drug delivery and bioadsorption. (c) 2012 elsevier inc. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000303422800045 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48098]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Huang SS,Li CX,Cheng ZY,et al. Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption[J]. journal of colloid and interface science,2012,376:312-321. |
| APA | Huang SS.,Li CX.,Cheng ZY.,Fan Y.,Yang PP.,...&Lin J.(2012).Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption.journal of colloid and interface science,376,312-321. |
| MLA | Huang SS,et al."Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption".journal of colloid and interface science 376(2012):312-321. |
入库方式： OAI收割
来源：长春应用化学研究所
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