Configuration-Dependent Diffusion Dynamics of Downhill and Two-State Protein Folding
文献类型：期刊论文
| 作者 | Xu WX ; Lai ZZ ; Oliveira RJ ; Leite VBP ; Wang J |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2012 |
| 卷号 | 116期号:17页码:5152-5159 |
| 关键词 | ENERGY LANDSCAPE TRANSITION-STATE STRUCTURAL CORRELATIONS STATISTICAL-MECHANICS ADENYLATE KINASE BARRIER HEIGHTS SPEED LIMIT ROP-DIMER FUNNELS MODEL |
| ISSN号 | 1520-6106 |
| 通讯作者 | wang j |
| 中文摘要 | configuration-dependent diffusion (cdd) is important for protein folding kinetics with small thermodynamic barriers. cdd can be even more crucial in downhill folding without thermodynamic barriers. we explored the cdd of a downhill protein (bbl), and a two-state protein (ci2). the hidden kinetic barriers due to cdd were revealed. the increased similar to 1 k(b)t kinetic barrier is in line with experimental value based on other fast folding proteins. compared to that of ci2, the effective free-energy profile of bbl is found to be significantly influenced by cdd, and the kinetics are totally determined by diffusion. these findings are consistent with both earlier bulk and single-molecule fluorescence measurements. in addition, we found the temperature dependence of cdd. we also found that the ratio of folding transition temperature against optimal kinetic folding temperature can provide both a quantitative measure for the underlying landscape topography and an indicator for the possible appearance of downhill folding. our study can help for a better understanding of the role of diffusion in protein folding dynamics. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000303426400006 |
| 公开日期 | 2013-05-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48182]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu WX,Lai ZZ,Oliveira RJ,et al. Configuration-Dependent Diffusion Dynamics of Downhill and Two-State Protein Folding[J]. journal of physical chemistry b,2012,116(17):5152-5159. |
| APA | Xu WX,Lai ZZ,Oliveira RJ,Leite VBP,&Wang J.(2012).Configuration-Dependent Diffusion Dynamics of Downhill and Two-State Protein Folding.journal of physical chemistry b,116(17),5152-5159. |
| MLA | Xu WX,et al."Configuration-Dependent Diffusion Dynamics of Downhill and Two-State Protein Folding".journal of physical chemistry b 116.17(2012):5152-5159. |
入库方式： OAI收割
来源：长春应用化学研究所
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