A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups
文献类型：期刊论文
| 作者 | Xiao HH ; Zhou DF ; Liu S ; Zheng YH ; Huang YB ; Jing XB |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2012 |
| 卷号 | 8期号:5页码:1859-1868 |
| 关键词 | ANTITUMOR-ACTIVITY ENHANCED PERMEABILITY PLATINUM COMPLEX DRUG-DELIVERY CISPLATIN OXALIPLATIN MICELLES CANCER NANOPARTICLES COPOLYMERS |
| ISSN号 | 1742-7061 |
| 通讯作者 | jing xb |
| 中文摘要 | a biodegradable and amphiphilic copolymer, mpeg-b-p(la-co-mcc), which contains pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (dach-pt) of oxaliplatin to form an mpeg-b-p(la-co-mcc/pt) complex. it was able to self-assemble into micelles with a mean diameter of 30-40 nm, and a surface potential near -10 mv. the typical platinum content was 10 wt.%. the micelles showed acid-responsive drug release kinetics, which is beneficial for drug release in the intracellular environment. the pt(ii) species were released mainly in the form of dach-pt-cl-2 in 150 mm nacl solution and dach-pt2+-(h2o)(2) in pure water according to the results obtained by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry and x-ray photoelectron spectroscopy. in vitro evaluation showed that the micelles displayed the same or higher cytotoxicities against skov-3, hela, and ec-109 cancer cells compared with oxaliplatin. the enhanced cytotoxicity against skov-3 cells is attributed to effective internalization of the micelles by the cells via endocytosis and the sensitivity of skov-3 cells to platinum drugs. this novel biodegradable and amphiphilic copolymer-based platinum drug will have great potential application in clinical use. (c) 2012 acta materialia inc. published by elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302989700020 |
| 公开日期 | 2013-05-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48195]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao HH,Zhou DF,Liu S,et al. A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups[J]. acta biomaterialia,2012,8(5):1859-1868. |
| APA | Xiao HH,Zhou DF,Liu S,Zheng YH,Huang YB,&Jing XB.(2012).A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups.acta biomaterialia,8(5),1859-1868. |
| MLA | Xiao HH,et al."A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups".acta biomaterialia 8.5(2012):1859-1868. |
入库方式： OAI收割
来源：长春应用化学研究所
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