Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery
文献类型：期刊论文
| 作者 | Zhang Z ; Gao XY ; Zhang AP ; Wu XW ; Chen L ; He CL ; Zhuang XL ; Chen XS |
| 刊名 | macromolecular chemistry and physics
 |
| 出版日期 | 2012 |
| 卷号 | 213期号:7页码:713-719 |
| 关键词 | BLOCK-COPOLYMER HYDROGELS CROSS-LINKED HYDROGEL DRUG-DELIVERY ENZYMATIC DEGRADATION CHALLENGES ADSORPTION RELEASE GROWTH |
| ISSN号 | 1022-1352 |
| 通讯作者 | chen l |
| 中文摘要 | a series of ph-dependent thermo-sensitive hydrogels for oral insulin delivery is designed and synthesized. in contrast to normal ph- and thermo-sensitive hydrogels, the release of oral insulin from them is mainly controlled by the adjustable swelling ratios in gastric and intestinal juice with their variable ph sensitivity. the release behavior of loaded insulin depends on the swelling/shrinking transition because of the changing lcst at different ph values. the hydrogels presented are composed of pnipaam chains and pmaa segments and are prepared with the biodegradable acryloyl-poly(?-caprolactone)-2-hydroxylethyl methacrylate as a crosslinker. the biodegradation rates of the hydrogels are directly related to their pmaa content. in vitro release of insulin from the hydrogels is investigated and the release profiles indicate that the smart hydrogels are of great promise in phtemperature oral insulin delivery systems. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302536900004 |
| 公开日期 | 2013-05-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48228]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang Z,Gao XY,Zhang AP,et al. Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery[J]. macromolecular chemistry and physics,2012,213(7):713-719. |
| APA | Zhang Z.,Gao XY.,Zhang AP.,Wu XW.,Chen L.,...&Chen XS.(2012).Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery.macromolecular chemistry and physics,213(7),713-719. |
| MLA | Zhang Z,et al."Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery".macromolecular chemistry and physics 213.7(2012):713-719. |
入库方式： OAI收割
来源：长春应用化学研究所
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