Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch
文献类型：期刊论文
| 作者 | Kang XJ ; Cheng ZY ; Yang DM ; Ma PA ; Shang MM ; Peng C ; Dai YL ; Lin J |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:7页码:1470-1481 |
| 关键词 | SUSTAINED-RELEASE PROPERTY POLY N-ISOPROPYLACRYLAMIDE CORE-SHELL STRUCTURE SENSITIVE HYDROGELS UP-CONVERSION BIOMEDICAL APPLICATIONS HYBRID COMPOSITES DELIVERY SYSTEMS NANOPARTICLES NANOCRYSTALS |
| ISSN号 | 1616-301x |
| 通讯作者 | kang xj |
| 中文摘要 | a novel approach for the fabrication of multifunctional microspheres integrating several advantages of mesoporous, luminescence, and temperature responses into one single entity is reported. first, the hollow mesoporous silica capsules are fabricated via a sacrificial template route. then, gd2o3:eu3+ luminescent nanoparticles are incorporated into the internal cavities to form rattle-type mesoporous silica nanocapsules by an incipient-wetness impregnation method. finally, the rattle-type capsules serve as a nanoreactor for successfully filling temperature-responsive hydrogel via photoinduced polymerization to form the multifunctional composite microspheres. the organicinorganic hybrid microspheres show a red emission under uv irradiation due to the luminescent gd2o3:eu3+ core. the in vitro cytotoxicity tests show that the samples have good biocompatibility, which indicates that the nanocomposite could be a promising candidate for drug delivery. in addition, flow cytometry and confocal laser scanning microscopy (clsm) confirm that the sample can be effectively taken up by skov3 cells. for in vitro magnetic resonance imaging (mri), the sample shows the promising spin-lattice relaxation time (t1) weighted effect and could potentially apply as a t1-positive contrast agent. this composite drug delivery system (dds) provides a positive temperature controlled on-offdrug release pattern and the drug, indomethacin (imc), is released fast at 45 degrees c (on phase) and completely shut off at 20 degrees c (off phase). meanwhile gd2o3:eu3+ plays an important role as the luminescent tag for tracking the drug loading and release process by the reversible luminescence quenching and recovery phenomenon. these results indicate that the obtained multifunctional composite has the potential to be used as a smart dds for biomedical applications. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302346400016 |
| 公开日期 | 2013-05-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48230]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang XJ,Cheng ZY,Yang DM,et al. Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch[J]. advanced functional materials,2012,22(7):1470-1481. |
| APA | Kang XJ.,Cheng ZY.,Yang DM.,Ma PA.,Shang MM.,...&Lin J.(2012).Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch.advanced functional materials,22(7),1470-1481. |
| MLA | Kang XJ,et al."Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch".advanced functional materials 22.7(2012):1470-1481. |
入库方式： OAI收割
来源：长春应用化学研究所
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