Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres
文献类型：期刊论文
| 作者 | Dai YL ; Ma PA ; Cheng ZY ; Kang XJ ; Zhang X ; Hou ZY ; Li CX ; Yang DM ; Zhai XF ; Lin J |
| 刊名 | acs nano
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:4页码:3327-3338 |
| 关键词 | NEAR-INFRARED LIGHT POLY(N-ISOPROPYLACRYLAMIDE) BRUSHES MAGNETIC MICROSPHERES SENSITIVE HYDROGELS DIBLOCK COPOLYMERS BLOCK-COPOLYMER NANOPARTICLES DELIVERY NANOCRYSTALS MICELLES |
| ISSN号 | 1936-0851 |
| 通讯作者 | cheng zy |
| 中文摘要 | in this study, we report a new controlled release system based on up-conversion luminescent microspheres of nayf4:yb3+/er3+ coated with the smart hydrogel poly[(n-isopropylacrylamide)-co-(methacrylic acid)] (p(nipam-co-maa)) (prepared using 5 mol % of maa) shell. the hybrid microspheres show bright up-conversion fluorescence under 980 nm laser excitation, and turbidity measurements show that the low critical solution temperature of the polymer shell is thermo- and ph-dependent. we have exploited the hybrid microspheres as carriers for doxorubicin hydrochloride (dox) due to its stimuli-responsive property as well as good biocompatibility via mtt assay. it is found that the drug release behavior is ph-triggered thermally sensitive. changing the ph to mildly acidic condition at physiological temperature deforms the structure of the shell, causing the release of a large number of dox from the microspheres. the drug-loaded microspheres exhibit an obvious cytotoxic effect on skov3 ovarian cancer cells. the endocytosis process of drug-loaded microspheres is observed using confocal laser scanning microscopy and up-conversion luminescence microscopy. meanwhile, the as-prepared nayf4:yb3+/er3+@sio2@p(nipam-co-maa) microspheres can be used as a luminescent probe for cell imaging. in addition, the extent of drug release can be monitored by the change of up-conversion emission intensity. these ph-induced thermally controlled drug release systems have potential to be used for in vivo bioimaging and cancer therapy by the ph of the microenvironment changing from 7.4 (normal physiological environment) to acidic microenvironments (such as endosome and lysosome compartments) owing to endocytosis. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000303099300055 |
| 公开日期 | 2013-05-22 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48244]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Dai YL,Ma PA,Cheng ZY,et al. Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres[J]. acs nano,2012,6(4):3327-3338. |
| APA | Dai YL.,Ma PA.,Cheng ZY.,Kang XJ.,Zhang X.,...&Lin J.(2012).Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres.acs nano,6(4),3327-3338. |
| MLA | Dai YL,et al."Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres".acs nano 6.4(2012):3327-3338. |
入库方式： OAI收割
来源：长春应用化学研究所
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