Understanding gene circuits at cell-fate branch points for rational cell reprogramming
文献类型：期刊论文
| 作者 | Zhou, JX ; Huang, S |
| 刊名 | TRENDS IN GENETICS
 |
| 出版日期 | 2011 |
| 卷号 | 27期号:2页码:55-62 |
| 关键词 | HEMATOPOIETIC STEM-CELLS TRANSCRIPTION FACTORS POTENTIAL LANDSCAPE PROGENITOR CELLS PU.1 GATA-1 DIFFERENTIATION SPECIFICATION EXPRESSION NOISE |
| ISSN号 | 0168-9525 |
| 通讯作者 | Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. |
| 英文摘要 | Cell-type reprogramming, the artificial induction of a switch of cell lineage and developmental stage, holds great promise for regenerative medicine. However, how does the metazoan body itself 'program' the various cell lineages in the first place? Knowledge of how multipotent cells make cell-fate decisions and commit to a particular lineage is crucial for a rational reprogramming strategy and to avoid trial-and-error approaches in choosing the appropriate set of transcription factors to use. In the past few years, a general principle has emerged in which small gene circuits of cross-inhibition and self-activation govern the decision at branch points of cell development. A formal theoretical treatment of such circuits that deal with their dynamics on the 'epigenetic landscape' could offer some guidance to find the optimal way of cell reprogramming. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 资助信息 | Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates) |
| 原文出处 | http://dx.doi.org/10.1016/j.tig.2010.11.002 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287349300003 |
| 公开日期 | 2013-05-17 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/14425]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Zhou, JX,Huang, S. Understanding gene circuits at cell-fate branch points for rational cell reprogramming[J]. TRENDS IN GENETICS,2011,27(2):55-62. |
| APA | Zhou, JX,&Huang, S.(2011).Understanding gene circuits at cell-fate branch points for rational cell reprogramming.TRENDS IN GENETICS,27(2),55-62. |
| MLA | Zhou, JX,et al."Understanding gene circuits at cell-fate branch points for rational cell reprogramming".TRENDS IN GENETICS 27.2(2011):55-62. |
入库方式： OAI收割
来源：理论物理研究所
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